So you're thinking about doing a #CRISPR screen... ENCODE Project is here to help! The CRISPR group is proud to share: “Multi-center integrated analysis of non-coding CRISPR screens” Lotsa great stuff inside for newbies and experts, here's a quick tour biorxiv.org/content/10.110…

Great article!

Great progress!

Great work, Arbel!

Scaling scRNA-seq data by log(p/s+1) outperforms other approaches, including recent methods with thousands of citations. [Ahlmann-Eltze & Huber, 2023 Nat Methods, nature.com/articles/s4159…]

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

Very cool!

Fantastic work! Everything I wanted after browsing gnomAD and seeing genes with few LOF variants with pLI/LOEUF scores I wasn't sure whether to trust.

A 🧵 on algorithms for predicting regulatory variant effects to help understand complex disease. IMO an extremely challenging problem that's at a glass mostly full / glass mostly empty point right now depending on who you ask.

Fantastic!

💛🐧yesterday, palmerpenguins reached 1 million CRAN downloads! The adoption & love this little data package has received over the past 3 years has been truly overwhelming. Here are some of my favorite (and maybe lesser known) moments from palmerpenguins’ history. 🧵1/11

Our work describing chromatin and gene expression programs in human scalp is now out in Nature Genetics. Congrats to Ben Ober-Reynolds and our other wonderful collaborators! nature.com/articles/s4158…

Students and postdocs working at the intersection of RNA and cancer, there is still time to apply for short talks and travel awards #RNACancerSRC

Graduate students are accusing the University of California of wage theft months after signing a contract that ended mass strikes. Some say they've been underpaid by $4k or more. What's going on? Check out my latest for STAT statnews.com/2023/09/05/uni…

🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today nature together with twitterless Kathy Collins's lab and The Nogales Lab UC Berkeley nature.com/articles/s4158… A 🧵

I had a great conversation that I’m so happy to share! Subscribe to the DASL pod, y’all.