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Excited to share our latest manuscript on "Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit" with Greg Gibson (Greg Gibson), medrxiv.org/content/10.110… [1/9]

Grad to see our Comment about inconsistent embryo selection across PRS methods is out in Nature Human Behaviour! nature.com/articles/s4156… Thanks again to the great collab with specialists for genetics/ELSI Masato Akiyama, Kazuto Kato, Soichi Ogishima, Kyuto Sonehara, Kenichi_Yamamoto_Osk, YukinoriOkada

日本人参照ゲノム配列JG1をアップデートしたJG2の論文がbioRxivに掲載されました！JG2は3名からフェーズドアセンブリを行って6セットのゲノム配列を構築し、これらの多数決を行うことで、日本人の代表的なアリルをより多くのサイトで搭載しています。

Please check our platform talk at #ASHG2024🎉 1. Deciphering genetic contribution of ancient hunter-gatherer Jomon in Japanese Populations, Kenichi_Yamamoto_Osk, Session 16. 2. Enhancing regulatory variant prioritization via long-range DNA seq and multi-task learning, Qingbo Seiha Wang, Session 73.

Thrilled for #ASHG24. Please check out our latest work about the impact of ancient hunter-gatherer on modern Japanese.

Genetic & phenotypic impact of ancient hunter-gatherer "Jomon" on modern Japanese🧬. Geographical diversity of Jomon genome proportion across Japanese islands🗾🏝️& link with obesity⚖️. Work with Kenichi_Yamamoto_Osk & Shigeki Nakagome using BBJ !! Now Nature Communications ㊗️ nature.com/articles/s4146…

Grad to see our latest work about the impact of ancient hunter-gatherer Jomon in the present-day Japanese populations is out in Nature Communications ! nature.com/articles/s4146… Thanks again for the great collaboration with YukinoriOkada, Shigeki Nakagome, and BBJ.

Insightful PRS study on T2D in the South Asian population‼️ Especially the results regarding BMI and complications are similar to our East Asian PRS study.

📢Blood DNA virome🧬🦠 assocites autoimmune diseases🔬. Endogeneous human herpesvirus 6B (eHHV-6B) has systemic lupus erythematosus (SLE) risk. Increased anellovirus in SLE, rheumatoid arthritis (RA), COVID-19 Nature Genetics📰#wgs #lupus #virus #covid #gwas nature.com/articles/s4158…

Human papillomavirus (HPV)🦠integration into human host genome🧬😃drives HPV+ head & neck cancers🦀. Tumor whole-genome seq identified intratumor clonal heterogeneity & genomic instability. Now in Nature Communications🎉 #cancer #genome #virus #HPV #wgs #papilloma nature.com/articles/s4146…

I'm delighted to present our nationwide effort to identify genetic determinants of child health and development in Japan. medrxiv.org/cgi/content/sh…

Our NMOSD paper has been published in Cell Genomics. Leveraging the genomics and single-cell data, our integrated study expanded the NMOSD risk catalog from germline to somatic variations. cell.com/cell-genomics/…

Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder dlvr.it/TJ6jDm

Germline ＆ somatic mutations at MHC & IGH define COVID-19 vaccine immunogenicity. mCA at 6p-MHC, 14q-IGH, mosaic loss of sex chromosome decrease vaccine titer but increase infection, allergy, rheumatic disease risk. Kyuto Sonehara 南宮湖(Ho Namkoong) Cell Genomics cell.com/cell-genomics/…

Our paper on germline/somatic mutations influencing COVID-19 vaccine immunogenicity is out Cell Genomics! cell.com/cell-genomics/…

I love this kind of research🐶🧬

How might polygenic risk scores enhance the management of type 2 #diabetes #genetics Diabetologia link.springer.com/article/10.100…

Pathway-stratified polygenicity🧬and single cell, metabolome, proteome projection revealed East Asian-specific negative genetic correlation between respiratory🫁& cardiometbolic🫀diseases (e.g. asthma/COPD↔️diabetes). Nature Communications #GWAS #PRS #PGS #proteome nature.com/articles/s4146…

Japan Omics Browser (JOB) japan-omics.jp by Yugo Takahashi & Qingbo Seiha Wang is published #BMCGenomics㊗️. Integrative visualization🎦of Japanese molecular QTL databases🧬💾. bmcgenomics.biomedcentral.com/articles/10.11… #QTL #pQTL #eQTL #GWAS

The Japan Omics Browser is a useful online resource that provides insights into how genetic variations influences molecular traits and disease outcomes, with a focus on Japanese populations🇯🇵