医学のあゆみ 特集「遺伝統計学の新潮流」が発刊されました。執筆頂いた皆様に感謝です。
amazon.co.jp/dp/B0CZ8SN3J4

Today, we discussed about a paper by YoshihikoTomofuji and YukinoriOkada on multi-omics analysis of host genotypes, gut microbiome and plasma metabolome. The main idea is to detect gut microbiome-host interaction through metabolites activities. 1/2 doi.org/10.1016/j.celr…

Looking forward to moderating the session of “From genotype to phenotype” We morning, and learning the cool things that YukinoriOkada found! #ACR23 🌟

If you are in ACR 2023 @ SanDiego, please join the joint ACR-JCR session for human genomics (Wed 8:00am, 31A-C). 15W106: From Genotype to Phenotype: Towards Integration of Genetics and Clinical Medicine. cdmcd.co/B7dgJw

Multi-omics network of Japanese (gut microbiome🦠 plasma metabolome🧪 host genome🧬) by YoshihikoTomofuji is now Cell Reports㊗️🎉.
ABO blood type🆎 associate with gut microbial genes related to N-galactosamine metabolism.
cell.com/cell-reports/f…

We are happy to announce that our multi-omics analysis of the gut microbiome (gut microbiome + human genotype + plasma metabolites) is finally published from Cell Reports (cell.com/cell-reports/f…)🎉🎉🎉! GWAS sumstats are available from NBDC (humandbs.biosciencedbc.jp/en/hum0197-v18…).

New application of knockoff genotypes (synthetic genotypes resembling original ones) for omics resources by Qingbo Seiha Wang. Knockoff–Finemap combination (KFc), a refined fine-mapping algorithm of eQTL to adjust PIPs. Now at NAR Genom Bioinform🎉㊗️
academic.oup.com/nargab/article…

Meanwhile, we have a new manuscript out.

Here we introduced the Knockoff-FINEMAP combination (KFc) method 🍗 and evaluated its performance in eQTL fine-mapping.

academic.oup.com/nargab/article…

TL;DR considering whether a gene has a causal variant at all is important.

Poster presentation by Yugo Takahashi (medical student) & Qingbo Seiha Wang got 'Reviewers' choice abstract' in ASHG meeting 2023㊗️🎉
Japan Omics Browser (JOB), integrative visualization of multi-omics data of Japanese.
Publickly available at japan-omics.jp
#ASHG2023 #eqtl #pqtl

👇Please check out platform talks from our group at #ASHG2023 in D.C.
1. Pan-cancer GWAS & shared genomics between prostate & breast cancers by Dr. Go Sato. Session 010. Thr Nov 2.
2. Cross-population Gene x Environmental (GxE) catlogue by Shinichi Namba . Session 020, Thr Nov 2.

🆕 #immunophenotyping of 46 peripheral immune cells in >1000 Japanese patients of 11 AIRDs 🗾

🎭 RA-like or SLE-like clusters were exclusively dominant

👉 clinically heterogeneous patient subtypes exist within single disease

🔗 bit.ly/49iHgnp

YukinoriOkada

【追加募集】東京大学大学院医学系研究科 遺伝情報学では、遺伝統計学やゲノム・オミクス解析による病態解明・創薬・個別化医療に一緒に取り組むIT系技術補佐員を【さらに一名】募集中です。バイオバンク・ジャパン(BBJ)のデータ解析チームの一員としても活躍して頂きます。
m.u-tokyo.ac.jp/news/jobs/2023…

Half or X chromosomes in females are inactivated (XCI), but some escape. scLinax: tool to quantify XCI escape using millions of single cells by YoshihikoTomofuji as Asian Immune Diverstiy (AIDA) Nework projects of Human Cell Atlas with Shyam Prabhakar Lab & colleagues. biorxiv.org/content/10.110…

We are happy to announce that our new preprint regarding the scLinaX, software to quantify escape from X chromosome inactivation from 10X scRNA-seq data, was released from bioRxiv 🎉🎉🎉!!
biorxiv.org/content/10.110…
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