Nice roundup on CRISPR genome editing The Economist economist.com/leaders/2025/0…

Top 5 advances in medicine this week (🧵) 1. Vitamin C modifies the amino acid, lysine, to form VitCyl-lysine This is a novel post-translational modification: it promotes immunity and (in mice!) boosts anti-PD1 immunotherapy to kill cancer Whether vitamin C can also boost

The origins and evolution of translation factors dlvr.it/TJkyL8

Delighted to have our Perturb-multiome paper, led by Jorge Diego Martin-Rufino and #AlexisCaulier from our lab, published today in Science Magazine. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: science.org/doi/10.1126/sc…

Fantastic Cancer Cell paper by Linghua Wang, MD, PhD MD Anderson Cancer Center revealing new biology in cancer-associated fibroblasts. cell.com/cancer-cell/fu…

Tour de force pancreas cancer study in @nature by Anirban Maitra (Anirban Maitra) MD Anderson Cancer Center, revealing profound transcriptomic heterogeneity & TME dynamics in metastases. Interesting CAF dynamics associated with cell state changes -- super cool. doi.org/10.1038/s41586…

A special Journal of Clinical Investigation series on #PancreaticCancer led by Ben Stanger jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… jci.org/articles/view/… Articles by Laura DeLong Wood Muir Lab Maddipati Lab

Clonal hematopoiesis (CH) is when blood cells carry mutations. It’s common with age—and sometimes a warning sign for cancer. But not all CH is equal. Why do some people progress, and others don’t? Check out Kelly Bolton MD PhD’s excellent thread and our paper here Nature Genetics 👇

Einstein Research: Study Identifies Biomarker that Predicts Response to Anemia Drug for Patients with #MDS. Learn more at: bit.ly/4eXr7Xt.

Great work. All the best.

Fantastic keynote by Professor George Vassiliou at #HEMSRC on clonal hematopoiesis.

Can LLMs predict the results of CRISPR screens in silico, before the experiment is run? A team led by Aly Khan, AI/ML head at #CZBiohubCHI, has built a scalable LLM-based prediction framework. Read the 📃 just accepted to #BioNLP workshop at @ACLMeeting! aclanthology.org/2025.bionlp-1.…

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain science.org/doi/10.1126/sc…

Great information. Thanks Anirban Maitra

Selective admiration: Take the best from your role models. Leave the rest. Because they’re human— and so are you. "If you don’t expect perfection from your role models, you’re less likely to demand it from yourself. Great write up Anne-Laure Le Cunff tinyurl.com/6jb73ver