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There are discussions that antibodies to SARS-like viruses might promote antibody-dependent infection (ADE). This would have big implications for vaccines / treatments, so I've been reading relevant papers in detail. Here are my thoughts (1/n).

Vaccines against SARS-CoV-2 will be very important. But don't get fooled by press releases. To get them will take time. Here is the overview again that I posted some time ago.

There is a lot of talk about #herdimmunity. Vaccination is the only safe way to achieve it. In the absence of vaccine, we need to practice #SocialDistancing. BioRender made this amazing infographic to explain how a hypothetical virus spreads through the population. (1/n)

GHOST TOWN: Downtown Chicago is eerily quiet. These pics were taken earlier today around 1 p.m. Coronavirus latest: bit.ly/2UolFnY Photos taken by Katie Carrillo and Ed Flynn

We designed a SARS-CoV-2 spike glycoprotein covalently shut closed, and showed it is also applicable to SARS-CoV, to support structural, immunology and serology studies for COVID-19 and coronavirus research. Led by Matthew McCallum biorxiv.org/content/10.110…

B and Helper T Cells Orchestrating the #Antibody_Response | A Synchronous IRF4-Dependent Gene Regulatory Network | Roger Sciammas UC Davis Trends in Immunology buff.ly/3dabLOS | #2020_ReCapMay

Speaker: “I’d appreciate it if everyone turns on their webcams, it’s nicer to see the faces of the people I’m talking to” You: x.com/buitengebieden…

healthtech.com/thechain/episo…

A stunner. One of my favorite graphics from the pandemic: the story of the unprecedented #SARSCoV2 vaccines Published today Nature Human Behaviour Our World in Data nature.com/articles/s4156… Edouard Mathieu Max Roser Hannah Ritchie Esteban Ortiz-Ospina Lucas Rodés-Guirao Lucas Rodés-Guirao Joe Hasell @appel_cam

Great presentation of the data from this new paper nature.com/articles/s4146…! Love seeing young investigators present cutting edge work! @camilahcoelho #AAI2021 "Immune Lessons from parasites"

Check out our new paper led by Siri in collaboration with peter 1/2mann from Yoshi Kawaoka's lab and Hejun Liu from Ina Wilson's lab describing a broadly cross reactive mAb to all SARS-CoV-2 variants. Overview:news.weill.cornell.edu/news/2023/04/r… paper: jci.org/articles/view/…

Many thanks to the thoughtful and comprehensive commentary from Shiv Pillai on our paper led by Siri about broadly protective mAbs against SARS-CoV-2, both out today in the JCI: Comment:jci.org/articles/view/… Paper:jci.org/articles/view/…

A broadly neutralizing antibody protects against multiple SARS-CoV-2 variants: buff.ly/3UsivOt @PatWilsonLab Siri @McGrath_Immuno @LeiLiOxford Weill Cornell Medicine #COVID_19 #Immunology

Does the SARS-CoV-2 spike really have an Achilles heel? buff.ly/40iLohn In this #Commentary, Shiv Pillai Ragon Institute highlights the molecular features that contribute to broad neutralization and discusses the implications for future SARS-CoV-2 vaccine development.

Virus imprinting matters: OC43-primed S2 antibodies show neutralizing potential & broad activity across five beta-#coronavirus subgenera, while #SARSCoV2-primed S2 antibodies remain narrow to sarbecoviruses & are largely non-neutralizing. Changrob et al.: hubs.la/Q03N5whG0

Don’t forget to... 🌤 focus on the good 🎨 do something you love 🌿 go outside 💕 love who you are now ✨ keep being brave