Please, please, please. Please make clear first what the hell is the so-called EMT or EMP...and what they can help understand cancer.🙏🙏🙏 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ cellandbioscience.biomedcentral.com/articles/10.11…

As generalized before, most cancer promoting (incl. resistance) genes are embryonic neural genes, incl. NSD2. They confer cancer cell with neural stemness, (therefore,pluripotency&tumorigenicity), which unifies cancer cell phenotypic traits, incl. resistance. nature

Consider neural stemness rather than a single protein as the ultimate factor that determines resistance and consider the pluripotent feature of cancer cell, which is determined by neural stemness, in cancer cell lineage plasticity. nature

‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/202…

Another possible factor: cancer (tumorigenic) cells ≈ neural (stem/progenitor) cells. ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/202… Nature Reviews Cancer

Understanding the basic relationship and cancer cell and cancer evolution (complexity). Note: most cancer promoting factors are neural stemness factors. Note: therapy resistance is one of cancer cell phenotypic traits, which are unified by neural stemness. preprints.org/manuscript/202…

As generalized before, most cancer promoting (incl. resistance) genes are embryonic neural genes, incl. NSD2. They confer cancer cell with neural stemness, (therefore,pluripotency&tumorigenicity), which unifies cancer cell phenotypic traits, incl. resistance. Epigenome Technologies Inc.

Consider neural stemness rather than a single protein as the ultimate factor that determines resistance and consider the pluripotent feature of cancer cell, which is determined by neural stemness, in cancer cell lineage plasticity. preprints.org/manuscript/202…

Beijing just announced they will PAY foreign scientists to do whatever research they like in China!! Its for international science scholars that graduated from top 500 global universities. China will let you pick your own research topic and get 200k RMB of funding per year to

The side effect of GLP-1R agonist in promoting cancer can be predicted by rules underlying tumorigenesis, or vice versa it confirms the rules. As I generalized before, most cancer promoting genes are embryonic neural genes, but TSGs are not. GLP-1R is an embryonic neural gene.

Knowing the rule below might help understand/avoid a side effect of promoting cancer when a disease is to be treated by promoting/blocking a gene. Cancer promoting genes are mostly embryonic neural genes, but cancer suppressor genes are mostly non-neural.

'GLP-1R agonist promotes..neuroendocrine neoplasm cells..'😮😩 As I generalized before, cancer promoting genes are embryonic neural genes, but TSGs are non-neural. Why GLP-1R promotes cancer? It is embryonic neural. Know the rules underlying cancer. surgjournal.com/article/S0039-…

Knowing the rules underlying tumorigenesis to predict/understand/avoid a side effect of tumorigenesis when selecting a gene as a target to treat diseases/abnormalities. Cancer promoting genes are mostly embryonic neural, but TSGs are mostly non-neural.

Cancer is the consequence of loss of original cell identity and acquirement of neural stemness. Whether a mutation causes cancer depends on its ability to confer neural stemness to cells. This is highly cellular context sensitive. preprints.org/manuscript/202… Cancer Grand Challenges

WOW. epithelial-mesenchymal transition. But please make clear first what the hell is the so-called EMT and what they can help understand cancer.🙏🙏🙏 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ link.springer.com/article/10.118…

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' link.springer.com/article/10.118…

'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/202…

Epithelial-mesenchymal transition!!! Those who believe EMT can help understand cancer should first make clear on what basis it stands as a concept or rule, otherwise EMT is just misleading.

'EMT' and cancer: It is not the mysterious mesenchymal state but the neural stuff that is truly critical for understanding cancer. The core property of cancer cell is neural stemness, which unifies different cancer cell phenotypic traits incl. metastasis,...

NAT10 promotes metastasis by modulating embryonic neural regulatory network, because most cancer promoting genes are embryonic neural genes incl. NAT10/P300, which confer cancer cells with neural stemness Neural stem/progenitor cells undergo single-cell migration. Molecular Cell