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I am very proud of the superstar postdoc Haojun Yang, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s4158…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Congrats Julia Phan + Aslan Tasdogan for their paper in Science today: hematopoietic stem cells (HSCs) & erythropoiesis get activated during pregnancy and after bleeding by retrotransposons that turn on in HSCs activating cGAS/STING & interferon signaling science.org/doi/10.1126/sc…

I’m thrilled to share this story from Joshua Mendell and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…

Thrilled to share that EVOLVEpro is now published Science Magazine Since our preprint, we now demonstrate low-N eningeering of both antibody and enzymes. We hope this model will broadly useful to the protein engineering field. science.org/doi/10.1126/sc…

EVOLVEpro, our general AI model for protein engineering, is now out in Science! We show the ability to design and evolve dozens of unique proteins to have up to 500 times more activity or function using a combination of LLMs and regression models. 🧵👇 science.org/doi/10.1126/sc…

Delighted to share our #NightScience tale: "A tetramer of BCL11A is required for stable protein production & fetal hemoglobin silencing," in Science Magazine. Co-led by Zheng Ge, Yin Maolu, & me, here’s a tweetorial about our puzzle-solving adventure! 1/7 tinyurl.com/2tpaaua3

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Super excited to share our new study from the Jason Buenrostro Lab in nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: nature.com/articles/s4158…

Big #RegenerativeMedicine advance! New study demonstrates the use of iPSC-heart muscle to treat a patient with heart failure. The patches successfully engrafted, contributing to heart repair. Patient survived 3 months before receiving a heart transplant nature.com/articles/s4158…

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Thrilled to be launching Terrain Bio today! Revolutionizing RNA medicines with our AI-powered design & manufacturing platform Helping biotechs get better mRNA candidates to patients, faster 🧬 #biotech #RNAmedicine w/ Jonathan Gootenberg Patrick Hsu Chetan and many others (awesome team!)

The latest from Gladstone Institutes of Cardiovascular Research and UC San Francisco: Isha Jain's lab, with an outstanding discovery of a small molecule that mimics hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, RA in Isha's lab, is first author! cell.com/cell/fulltext/…

The massive changes in US research brought about by the new administration of President Donald Trump are causing many scientists in the country to rethink their lives and careers go.nature.com/4cbUXX0

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. Erquan Zhang Susan Golden @ Society for Research on Biological Rhythms rdcu.be/efxV8

Inserting large, scarless DNA sequences is a major hurdle for gene therapy. We explored if site-specific retrotransposons, natural genome editors found across the tree of life, could be engineered for this task. Excited to share STITCHR in nature with Jonathan Gootenberg!

Stem cell therapy for Parkinson’s disease has entered a new era. Two nature studies demonstrate that pluripotent stem cell–derived dopamine neurons can survive, restore function, and potentially change the treatment paradigm for this neurodegenerative disease.

PAPER ALERT! Excited to share my PhD work in the lab of @larsplus Centre for Genomic Regulation (CRG). We screened minimalistic synthetic enhancers throughout myeloid differentiation. We uncovered widespread dual activator-repressor functions for individual TFs and TF pairs tinyurl.com/4z3rntyz (1/n)

Repeat-element RNAs integrate a neuronal growth circuit: Cell cell.com/cell/fulltext/…