Rapid protein evolution by few-shot learning with a protein language model - EVOLVEpro, PLMs with active learning, enables rapid and efficient evolution of protein activities. Show promosing optimization of Antibody, CRISPR Nuclease, Prime Editor, Integrase, and T7 RNA Polymerase

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules