Really pleased to share the detailed protocol for Micro Capture-C in nature protocols. It is capable of generating 3C data down to base pair resolution. jdavieslab Hangpeng Li Joseph Hamley MRC MHU MRC WIMM rdcu.be/c8GWN

Today we report in Nature Biomedical Engineering ex vivo prime editing of blood stem cells from sickle cell disease (SCD) patients, followed by transplantation into mice, correcting the SCD mutation to wild-type hemoglobin and rescuing SCD blood abnormalities. drive.google.com/file/d/11dcKAt… 1/12

In 2016 I looked after a girl who died during a transplant for HbE beta-thalassaemia. I am overwhelmingly pleased that we have been able to correct HbE with near 100% efficiency using base editors. nature.com/articles/s4146… Brilliant work from Mohsin Badat @Montytrench jdavieslab

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by Andrew Kwok and published in Nature Immunology, identifies a subset of immature neutrophils which is increased in severe sepsis. Big thanks to everyone involved!

🔥🔥🔥🔥🔥🔥 MAJIC study published in Journal of Clinical Oncology Ruxolitinib (rux) Versus Best Available Therapy (BAT) for Polycythemia Vera (PV) Intolerant or Resistant to Hydroxycarbamide (HC) in a Randomized Trial ascopubs.org/doi/10.1200/JC…

Delighted to share our new approach for high fidelity sc genotyping combined with scATAC - called GTAC! Do check it out! We love it. Great collaboration with the Hughes and Davies labs also in the WIMM. Credit to Sven, Asger, Angus and all co-authors. cell.com/cell-stem-cell…

Would highly recommend applying to this position! Such a wonderful group of people doing really important work for infant and childhood leukemia.

Our work from my master’s project exploring cytosine base editors for gene editing in Drosophila is now published Science Advances (my first first-authorship🎉) science.org/doi/10.1126/sc… There are several additions since the preprint, so read along for a 🧵with the main points:

Today we report in Cell a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing. sciencedirect.com/science/articl… PDF:drive.google.com/file/d/11959ct… (1/15)

Very exited to share that our work showing the importance of SOX2 pioneer activity for gene activation has now been published in The EMBO Journal. Excellent work from MichEla and Teun van den Brand. And a nice collaboration with James Davies (+lab). embopress.org/doi/full/10.15…

Very happy and honored to present our work from my postdoc project in @DaanNoordermeer lab I2BC Paris-Saclay on CTCF clustering at TAD boundaries and the novel multi-contact 3C assay: Nano-C – now published Nature Communications. nature.com/articles/s4146…. A nice 🧵 written by Daan 👇

We are looking for an RA to join the lab to work on a fantastic genomics project! jobs.ac.uk/job/DCH089/res… Closing date next week! Please RT - thank you!

Delighted that Nucleome is showcased as one of the 50 companies in PwC UK’s 'Life Sciences Future 50' report, illustrating the world-class science and innovation being led by the UK’s life sciences sector. Read the report here: bit.ly/3Fnw379

Remarkable to see that our discoveries over 15 years ago would enable such tremendous advances for sickle cell disease and thalassemia!!! Incredible to think that the final sentence of our 2008 paper would be prophetic (science.org/doi/10.1126/sc…)... statnews.com/2023/11/16/u-k…

New Nature Medicine paper from Boston Children's Wellcome Sanger Institute and York Biomedical Research Institute on clonal dynamics of HSCs pre- and post-gene therapy. 👍 @AlyssaHCull Mike Spencer Chapman 👍 Gracious for both the funding and the network connectively from Gates Foundation nature.com/articles/s4159…

Delighted to see this great News & Views article written by Jim R. Hughes and James Davies on our recent GAGE-seq paper Nature Genetics -- Single-cell technologies meet Hi-C. A fantastic read! nature.com/articles/s4158…

Very proud of this product of ⁦IRDiRC⁩ N=1 task force with collaborators also from ASO field ⁦N1 Collaborative⁩ ⁦n-Lorem Foundation⁩ The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap | Nature Reviews Drug Discovery nature.com/articles/s4157…

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

Thrilled that our paper is finally in press Science Magazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from Lauren Murphy below. Check out the news feature science.org/content/articl… and terrific editorial from Dennis Lo