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To shorten a guide catheter: Trim 10–15 cm from the guide’s proximal end. Use a femoral sheath 1 Fr smaller than the guide. Cut a 2 cm sheath piece as adapter, flare both ends and slide adapter over the cut ends of the guide. #CathLabHack #InterventionalCardiology

5 advances in medicine this week 1. One-and-done cholesterol therapy This is an epigenetic editor of PCSK9 — to silence its expression with a one-off dose and lower cholesterol (here in macaques) This complements existing phase 1 human data from Verve Therapeutics for a

How to treat orthostatic hypotension in Parkinson and Parkinsonism? Dizziness on standing? Melissa Armstrong nails it in one slide during her plenary lecture this morning at MDS Hawaii. ⁦MDS⁩ ⁦Norman Fixel Institute for Neurological Diseases⁩

The dominant blues and reds weren’t random. Blue symbolized heaven and divine truth, red symbolized Christ’s sacrifice and royal power. The contrast created what medieval theologians called lux nova — “new light,” a foretaste of paradise.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body. The Nobel Prize laureates

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

One of the goals of Sensible Medicine is to teach evidence appraisal. Few better lessons exist than the story of thrombolysis in acute stroke. Part 2 is up this week. If you thought NINDS was something, wait to you see this second chapter sensible-med.com/p/part-2-the-o…

$AMD - AMD CEO SAYS UNDER OPENAI DEAL TO TAKE STAKE IN AMD ALSO DIRECTLY TIED TO INCREASING AMD STOCK PRICE MILESTONES, WITH THE FINAL TRANCHE VESTING AT A PRICE OF $600 PER SHARE.

Three main rea­sons to un­der­go surgery in the set­ting of acute IE:  1. HF 2. Un­con­trolled in­fec­tion 3. Pre­ven­tion of sep­tic em­boliza­tion (Cere­bral em­boli) Tim­ing of surgery ▪︎ Emer­gen­cy (with­in 24 h), ▪︎ Ur­gent­ (with­in 3–5 days) ▪︎ Non-​ur­gent

Young man with chronic aortic regurgitation (wide pulse pressure)

John Mannisi MD 🇺🇸🇮🇹❤️‍🩹🏃 Full metal jacket to lad?

We authored this state-of-the-art review, now published in JACC, to provide an updated, comprehensive overview of post–myocardial infarction inflammatory mechanisms and to critically evaluate the emerging clinical evidence on anti-inflammatory therapies for secondary

Opinion from Lex: OpenAI is rolling out data centres like nobody's business. In the process, Sam Altman's company is constructing something else too: a corporate empire of mutual dependencies. on.ft.com/47bMgLo

Another day at the office... Another chapter of #RotaTripsy... 76y, 20% LVEF, rejected from surgery... #bifurcation #CHIP #ComplexPCI Manuel Pan Soledad Ojeda PCRonline 🫀 MIЯVΛƬ #IC ༄ ｡° Mamas A. Mamas jedicath աǟզǟʀ.ǟɦʍɛɖ ROTAMONSTER Alfonso Jurado-Román Salman Arain Tsutomu Fujita MD Cardiovascular Research Foundation

Major AI Chip deal list 🔹 NVIDIA & OpenAI – Up to $100B investment + chips 🔹 NVIDIA & Intel – $5B for ~4% stake 🔹 CoreWeave & NVIDIA – $6.3B capacity order 🔹 AMD & OpenAI – Multi-year AI chip deal + option for ~10% equity stake 🔹 Oracle & OpenAI – $300B cloud deal (5 years)

Precisely!

RIP Data Scientists. The Generative AI Data Scientist is NOW what companies want. This is actually good news. Let me explain:

🚨 The older the sperm, the more likely it is to cause autism Sequencing sperm using nearly error-free sequencing → measure % sperm carrying disease-causing mutations: 2% at age 30 → 4.5% at 70 Most were autism genes New paper in nature today 🧵

The Italian Army band’s music filling the ancient theater of Taormina, Sicily – Italy 🇮🇹 The result is absolutely breathtaking ✨