Check out our latest iteration of predicting gene expression and chromatin descriptions from DNA sequence, with a meaningfully improved ability to make use of distal regulatory elements [biorxiv.org/content/10.110…]

A game changer - identifying target genes in cis and/or trans for multiple GWAS plausible causal variants in single cells at scale! Beautiful work (STING-seq) led by John Morris, Tuuli Lappalainen & Neville Sanjana! biorxiv.org/content/10.110…

The last date for international students to apply for the UG programme 2021-22 at IISc has been extended to May 30, 2021. More details at: oir.iisc.ac.in/index.php/anno…

In the latest issue! Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease @sbmontgom Stanford Medicine bit.ly/3feqkTQ

Does chronic disease need to equal chronic care? No 👇in nature from Verve Therapeutics One-time base editing Rx (in vivo liver), durable⬇️LDL-C In monkeys: *⬇️90% PCSK9,⬇️60% LDL-C, now out to 10 mos * VERVE-101: efficacy at LNP doses as low as 0.5 mg/kg nature.com/articles/s4158…

Ever wondered if the mitochondrial DNA affects common disease risk? Well take a look at our work out Nature Genetics We re-called & analyse mtDNA SNPs in 100s of traits in UK Biobank found assoc of mtDNA SNPs with T2D MS liver&kidney fct & blood cell params. rdcu.be/ckK9v

Beautiful perspective Nature Medicine about the impact of the Human Cell Atlas on medicine by Jenny Rood, Ph.D. with Sarah Teichlab and Aviv Regev. Great summary of resources as well as open challenges! nature.com/articles/s4159…

Excited to share our latest work on membrane endocytosis of molecular condensates formed by liquid liquid phase separation, out now in Nature Communications Springer Nature! We determine the mechanical behavior of membrane that control the endocytic pathway 1/n nature.com/articles/s4146…

A successful conference for UChicago Human Genetics at #probgen23 💻🧬 Thanks for having us CSHL Meetings Cold Spring Harbor Laboratory

Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)