What if, in the presence of a pancreatic tumor, the prevention of muscle wasting via deletion of a muscle specific gene, slowed tumor growth and extended survival? Muscle wasting as a driver of tumor growth. Cancer Cachexia Society Read more here: nature.com/articles/s4200…

The hunger strikes back: an epigenetic memory for autophagy nature.com/articles/s4141…

A cellular and molecular spatial atlas of dystrophic muscle pnas.org/doi/10.1073/pn…

Assessment of LV samples pre- & post-#LVAD therapy reveals that increased autophagy may underlie reverse remodeling seen w/ mechanical unloading. Read the new study by Thomas Martin, Miranda J., et al: bit.ly/3RHIDFC #JACCBTS #HeartFailure #CardioTwitter CU Boulder 🦬

A study in Nature Aging examines fasting in killifish and finds that older animals exhibit a metabolic shift resembling a fasting-like program, which is counteracted by boosting the activity of AMPKγ1, promoting health and longevity. go.nature.com/40Jj3Cx

Fiber type traps: revisiting common misconceptions about skeletal muscle fiber types with application to motor control, biomechanics, physiology, and biology. journals.physiology.org/doi/abs/10.115…

Ubiquiton—An inducible, linkage-specific polyubiquitylation tool: Molecular Cell cell.com/molecular-cell… Molecular Cell

Mutations to the co-chaperone protein BAG3 can cause DCM. The disease-enhancing mechanism may be shared by variants regardless of location. #AHAJournals Thomas Martin Jonathan Kirk Loyola University Chicago ahajrnls.org/3RSUmAN

Combining hGRAD w/ Nascent-seq & iCLIP2 allows the identification of direct SRSF5 targets & reveals a function of SRSF5 in transcript stabilization. From Arnold, Riegger, @mixmue et al. Goethe-Universität introducing a new system called hGRAD: hubs.ly/Q02dgXLj0

CFP NATIONAL CHAMPS 🏆〽️ Michigan wins its first National Title since 1997 👏

Lactate- and immunomagnetic-purified hiPSC–derived cardiomyocytes generate comparable engineered cardiac tissue constructs: buff.ly/3O65acz Ying Ge UW–Madison #Cardiology #StemCells

After a year hiatus, Behind the Bench is back! Had such a great time learning about the awesome research being performed by the DeWayne Townsend lab. DeWayne is also just an incredible science communicator. Give it a listen!

#Review: Hearts apart: sex differences in cardiac remodeling in health and disease: buff.ly/3xFG6nY part of #ReviewSeries: buff.ly/3RQrcBX MCDB at CU Boulder💉😷🧬

In this editorial, Drs. Thomas Martin and Leslie Leinwand discuss findings of decreased protein synthesis but increased mRNA expression in the infarct zone after experimental myocardial infarction. bit.ly/3y3gu4q #cvCAD #cvMI #JACCBTS

Excited to share the preprint on our recent collaborative work with the BurdickLab on engineered heart tissues!

Thrilled to share recent work from the Leinwand Lab deciphering molecular mechanisms of cardiac plasticity in Burmese pythons: Regression of postprandial cardiac hypertrophy in Burmese pythons is mediated by FoxO1 | PNAS pnas.org/doi/10.1073/pn…

We had such a great time hosting LoyolaPhysiology graduate student Hannah Cizauskas on our pod Behind the Bench from AJP-Heart and Circ Hannah is a wonderful scientist and person and was such a joy to chat with. Give it a listen!

Printed hydrogels have promising applications from in vitro drug screening to tissue engineering. In this Review, BurdickLab @apdhand & Mathew Davidson discuss lithography-based 3D printing and provide a guide to print hydrogels for clinical applications. go.nature.com/3NuvsEW

Want to know what’s near your RNA of interest? Oligonucleotide-mediated proximity-interactome MAPping (O-MAP) from the Shechner lab enables precise multiomic characterization of biomolecular interaction networks (DNA, RNA, and proteins) at target RNAs. nature.com/articles/s4159…

In the latest issue! SnapShot: Targeted protein degradation dlvr.it/TGGVy0