Never put dust under the carpet.
A great summary of the 10-times deadlier Mpox clade Ib outbreak that is ongoing in Congo. science.org/content/articl…

1/ World Health Organization (WHO) has published a report on updated terminology for disease transmission

I've seen some debate about it. My take:

- Terminology itself is ok. Big progress
- But no recommendations of how to protect!

Report: who.int/publications/m…

Press release: who.int/news/item/18-0…

Bird flu is ravaging mammals worldwide & the pandemic clock is ticking.
Convalescent plasma will again be our first-line therapy.
H/t Arturo Casadevall Michael Joyner Andrew Pekosz @fabrizi66265683

Tom Peacock Thijs Kuiken Marion Koopmans, publications: https://pure.eur.nl Bart Rijnders Tulio de Oliveira

onlinelibrary.wiley.com/doi/10.1002/rm…

Are we FLiRTing with a new Covid wave? New data on age-specific Covid interactions and self-amplifying vaccines. In the new Ground Truths (link in profile).
Thanks JWeiland Daniele Focosi, MD PhD MSc Federico Gueli 🏳️ Ben Murrell and so many others for continuing to keeping close 👀 on #SARSCoV2

Repubblica delle banane. ilfattoquotidiano.it/2024/04/18/rep…

Great work by Ben Murrell out now with the new growth advantages of all the circulating variants:
github.com/MurrellGroup/l…
Perfectly matching the early warning (and tracking) of variant community especially Xu Zou Cornelius Roemer Josette Schoenmakers Krosa1910 ..cont

The world was missing bovine practioners-driven phylogenies.
bovinevetonline.com/news/industry/…

No comment. ilfattoquotidiano.it/2024/04/15/dec…

So, in the EU we can feed pigs (not cows) with poultry litter. 🤦‍♂️

From wild birds to poultry to cows to humans.
#onehealth #birdflu

🤦‍♂️ telegraph.co.uk/global-health/…

'When stupidity is considered patriotism, it is unsafe to be intelligent.'

-- Isaac Asimov

For those following the Michael Joyner vs. Mayo Clinic here is an article covering yesterdays hearing.
thecollegefix.com/mayo-clinic-ar…

Mammary transmission of H5N1 virus via milking machines would be a remarkable alternative to respiratory transmission via air!
References:
2. doi.org/10.3390/v13020…
3. doi.org/10.3201/eid140…
4. aphis.usda.gov/news/agency-an…
5. https://doi:10.1371/journal.ppat.1005173

Nirmaltrelvir/ritonavir (Paxlovid) led to benefit in patients at standard risk.
nejm.org/doi/full/10.10…
I’d not be surprised if the PANORAMIC RCT (just closed) will show another fail:
panoramictrial.org
I hope someone draws conclusions about the “we have the tools” motto.

HPAI A(H5N1) #birdflu sounds like doomsday clock.
USA has affected birds in 48 states and affected livestock in 6 states
aphis.usda.gov/livestock-poul…

cdc.gov/flu/avianflu/d…

Meanwhile Vietnam reported a fatal case suggestive of asymptomatic circulation.
who.int/emergencies/di…

If I’m not wrong this sequence has NP:Y52H, a mutation which Rute Maria Pinto and Spyros Lytras linked to immune evasion to BTN3A3, a restriction factor for human infection by avian influenzavirus.
nature.com/articles/s4158…

Raj Rajnarayanan Tom Peacock Ryan Hisner

Some points of progress in the past century of 6 pandemics
jci.org/articles/view/… by Arturo Casadevall Journal of Clinical Investigation

Genetic analysis by CDC of highly pathogenic avian influenza virus from person in Texas who contracted infection from infected cows at a dairy farm. Virus identified as clade 2.3.4.4b of A/Goose/Guangdong/1996 lineage, H5N1 subtype. #vogelgriep 1/3
cdc.gov/flu/avianflu/s…

APR 4 UPDATE: convergent evolution of JN.* Spike hits “level 4” (346+455+456+572I) with KW.1.1 and KZ.1.1.1

Yunlong Richard Cao Raj Rajnarayanan The Sato Lab (Kei Sato) Ben Murrell Etienne Simon-Loriere Eric Topol T. Ryan Gregory Ryan Hisner Marc Johnson Cornelius Roemer Federico Gueli 🏳️ Ben Murrell