If you are convinced that microbes are causal of infectious diseases, please take a breath, and consider the alternative possibility that infection with a trigger microbe reveals a preexisting cause of disease in the host: annualreviews.org/content/journa…

(1) First post-doc paper alert!!! 🚨🚨🚨 We are happy to share our new study, “SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency”, published in Journal of Experimental Medicine! doi.org/10.1084/jem.20…

(1) Quick salvo of studies in tackling the enigma of viral encephalitis! 💫💫 We are happy to share our new finding, “Human TMEFF1 is a restriction factor for herpes simplex virus in the brain”, just out in nature! (nature.com/articles/s4158…). 🧵 below!!

It's a very special day for me. I am so excited and grateful for this opportunity. My lab will study the role of mRNA translation in human immunity. Reach out if you're interested to join us. Gene Center Munich Universität München

1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in nature about humans with inherited TNF deficiency: nature.com/articles/s4158….

Glad that this story made the cover Journal of Experimental Medicine :-)

Genes that affect SARS-CoV-2 infection: Jérémie Le Pen Rice Lab &co use genome-wide #CRISPR KO screen to identify 28 genes that impact #SARSCoV2 infection, including PLSCR1, which restricts spike-mediated #virus entry IFN-independently #PLOSBiology plos.io/3XYd0up

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc Casanova Lab, published in Journal of Clinical Investigation If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/… 1/8

Check out our latest paper published in PLOS Biology, “A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.” journals.plos.org/plosbiology/ar… 🧵1/10

1) Delighted to share our review on Genetic Defects of Brain Immunity in Childhood Herpes Simplex Encephalitis (HSE), just out nature. Our expedition began in 2003, searching for monogenic defects underlying HSE. nature.com/articles/s4158…

Shuo Ru, Daxing Gao et al. show that the accumulation of RNA lariats in human DBR1-deficient cells impairs #StressGranule assembly–mediated PKR activation, and thereby cell-intrinsic antiviral immunity. hubs.la/Q02-zrTc0 Casanova Lab Shen-Ying Zhang #Immunodeficiency

There are now >550 inborn errors of immunity 🧬. Latest update from IUIS IEI c’tee is now available on IUIS website & will be formally published soon. Great to be part of this team providing an important resource for all. Well done Isabelle Meyts Cecilia Poli & all ctee members!

1/ We are proud of our former trainees and will be highlighting their accomplishments from time-to-time. First up is Satoshi Okada, appointed Chief Professor of the Department of Pediatrics at Hiroshima University in 2020 and advanced to Head of the Program of Medicine in 2024.

The 2025 Novo Nordisk Prize goes to Professor Jean-Laurent Casanova for his pioneering genetic discoveries! For decades, scientists believed that infections were determined solely by viruses and bacteria. But Professor Jean-Laurent Casanova’s groundbreaking research has revealed

1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in Journal of Experimental Medicine uncovers the underlying immunological mechanism   rupress.org/jem/article/22…

/ I was honored to accept the 2025 Novo Nordisk Prize from Novo Nordisk Foundation at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of BioInnovation Institute, lunch at Novo Nordisk Foundation, and an evening award celebration and dinner.

1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)

1/ Today we are proud to feature our former trainee Xiao-Fei Kong – a PhD student (2007-10), postdoc (2010-12) and finally an instructor of clinical investigation at Rockefeller University (2012-15) who is now a physician-scientist and assistant professor at UTSW Internal Medicine

Very happy to share our review Vijay Sankaran published today in JHI. We discuss how rare and common genetic variants influence early B cell development and can underlie susceptibility to infectious diseases, autoimmunity and leukemia. 🔬🧬

What nature teaches us about the essential role of an ancient RNA sensing pathway in humans through rare diseases. science.org/doi/10.1126/sc…