Lui, Hoenig et al. Elena Hsieh lab describe a human LCK variant causing partial loss-of-function incl. defective TCR signaling & T cell development. hubs.la/Q02sjj5M0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjxR20

Choi, Love et al. show that the main function of GRB2 in thymocytes is to facilitate THEMIS-mediated inactivation of the tyrosine phosphatase SHP1. hubs.la/Q02sjhqF0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjmc60

A conserved transcriptional program for MAIT cells across mammalian evolution, from Bugaut, El Morr, @Lablegoux and colleagues: hubs.la/Q02sjxyf0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjj5L0

Jain et al. Boston Children's discuss recent findings on how immune cells instruct the development and persistence of adaptive and maladaptive pain states by modifying neural activity in the end organs, nerves, dorsal root ganglia, spinal cord, and brain. hubs.la/Q02sHS7k0

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant, from E. Bernaldo-de-Quirós, Correa-Rocha et al. LIR lab-Madrid #immunology: hubs.la/Q02sjjTk0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjxxk0

Lin, Chen et al. UCLA Chemical and Biomolecular Engineering Parker Institute for Cancer Immunotherapy show that CAR-T cells engineered to secrete cytokine modulators can reduce cytokine release syndrome-related toxicity while simultaneously improving in vivo antitumor efficacy. hubs.la/Q02sHzDm0

#TumorImmunology #Immunotherapy

Immune acting fibroblasts on the cover of JExpMed ! 🤩

Abdulla et al. show that overexpression of Lmo2 initiates T-lymphoblastic #leukemia via impaired thymocyte competition. hubs.la/Q02sjs7B0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjtp20

ICYMI... check out the #JEM_Spotlight study picked by Montse Cols! twitter.com/12663822516061…

See #JEM_Spotlight for April to celebrate #HKS2024 , from Daniel Michelson, Diane Mathis and colleagues on Hnf4 activating mimetic-cell enhancers to recapitulate gut and liver development within the #thymus bit.ly/3ri9opa. Come and say hi 👋!

Helper T cell immunity in humans with inherited CD4 deficiency, from Guerin Antoine, TangyeLab and colleagues: hubs.la/Q02sjj6K0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjkS40

McElwee et al. show that the CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune #tolerance . hubs.la/Q02sjrXr0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjm3L0

ICYMI: we present a special magazine w/ some of the research articles from our Cancer Collection (hubs.la/Q02rQ2--0), as well as cancer research published in other Rockefeller U. Press journals, JCellBiol & LifeScienceAlliance. Download the PDF ▶️ hubs.la/Q02rQj-30

Tanaka, Sakaguchi et al. provide a general model of how altered TCR signaling evokes autoimmune disease. hubs.la/Q02sjrm70

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjs8w0

The studies in our #Cancer Collection unravel the mechanisms driving cancer initiation, progression, and #metastasis across diverse malignancies, and hold immense potential in reshaping the trajectory of cancer treatment. ➡️ hubs.la/Q02ry_YR0

#AACR2024

Inherited human ITK deficiency impairs IFN-γ immunity and underlies #tuberculosis . From Masato OGISHI, Stephanie_Boisson-Dupuis et al. Casanova Lab: hubs.la/Q02sjvnF0

Part of our collection on Thymus, T Cell Development, and Inborn Errors: hubs.la/Q02sjx0x0

Wu, Kyle Travaglini, Arjun Rustagi, BlishLab, Krasnow et al define cellular tropism & transcriptomic effects of #SARSCoV2 virus. Interstitial #macrophages are a dominant target of viral takeover, #inflammation , & destruction in #COVID19 initiation. hubs.la/Q02sqFTg0

Insights from Pires and Longman Weill Cornell Medicine IBD: Schmitt et al (hubs.la/Q02sqvkz0) identify TL1A as an epithelial alarmin constitutively expressed by a subset of lung epithelial cells, which is released in response to airborne microbial challenge hubs.la/Q02sqmcH0

Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation - IPBS-Toulouse
✍️ Corinne Cayrol, Jean-Philippe Girard and colleagues ipbs.fr/respiratory-al…