What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

"Tweeting about science will 100% get you a PI job" - Caleb Lareau #singlecellgenomicsday

Talk by Caleb Lareau on rare cell analysis with single-cell sequencing - first paper from the lab with a deep commitment to sharing methods and data #singlecellgenomicsday

We’d like to celebrate the innovation of PERFF-seq by Tsion Abay @ChaligneRonan Ansu Satpathy & @caleblareau! Their work, which leverages the Chromium Flex assay, will pave the way for new studies of rare cells. 👏

See our new preprint pairing Oxford Nanopore single-cell sequencing with 10x Genomics for full-length antibody repertoire sequencing of single B cells, in collaboration with Prof. Dr. Benhur Lee, MD 🦠🧬🔬 at Icahn School of Medicine at Mount Sinai. A thread 🧵 (1/14) biorxiv.org/content/10.110…

Latest pre-print just out biorxiv reporting our continuing collaboration with the Beers Lab @WestPhillyTough: "Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis" biorxiv.org/cgi/content/sh… #biorxiv_molbio

Sangho Lim and collaborators report mouse #thymus #organoid lines that can be expanded for years, represent cortex and medulla and sustain T cell development in vitro and in vivo. The Clevers Lab cell.com/cell-reports/f…

SciArt profile: Maja Mielke In this latest #SciArt profile, we meet Maja, who is doing a PhD in functional morphology and enjoys making nature-inspired drawings: 🖼️thenode.biologists.com/sciart-profile…

10X NYC UGM: Michael Bronson championing the message of the day - “Get More!” The latest product announcements from 10X deliver HD resolution, more FLEXibility, and increased sensitivity! Our innovation Roadmap exemplifies 10X’s commitment to more, for less.

10X NYC UGM: Dr Judy Cho delivering an absolute Master Class on leveraging single cell alongside additional modalities to maximize biologic insight to Inflammatory Bowel Disease. From immune-stromal cross talk, to GWAS fine-mapping, to capturing inflammatory context with spatial

10X NYC UGM: Wonderful presentation from Dr. Kristin Beaumont highlighting the 3-pronged approach her group leverages to tackle complex problems. Demonstration of Visium SD and HD benchmarking data in NSC Lung Cancer and the improved detection of cell types at a 16uM bin size.

🥳new pre-print alert! VEXAS syndrome deciphered - From single-cell genotype-to-phenotype mapping aaaall the way to mechanism and therapeutic vulnerability discovery! biorxiv.org/content/10.110…

Hello Xverse, we're on the hunt for a postdoctoral fellow to study cellular and systemic metabolism with a quantitative, multimodal toolkit. Is this you or someone you know and love? Reach out!

PERFF-seq is out today in Nature Genetics! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states. nature.com/articles/s4158…

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!

Incredible tool. The ability to use natural language to analyze single cell and spatial transcriptomic data will drastically reduce time to insight, open analysis capabilities to just about everyone, and remove one of the biggest hurdles to starting new research projects!