In our latest News and Views: Marina Sirota and colleagues UCSF Bakar Computational Health Sciences Institute discuss new data on the application of #machinelearning to personalisation of routine laboratory tests Marina Sirota nature.com/articles/s4159…

Study investigates DNA methylation landscapes of 1538 breast cancers from the METABRIC cohort and reports epigenomic instability and cis-regulatory effects. Rajbir Nath Batra Aviezer Lifshitz CaldasLab #CancerResearch @natrescancer nature.com/articles/s4146…

Now on Genome Biology: genomebiology.biomedcentral.com/articles/10.11… Code: github.com/tanaylab/metac… Docs: metacells.readthedocs.io/en/latest/

Congratulations to my sister and brother in-law! שולמית ליפשיץ orielBerkovits And to my daughter who is the lead actor! youtu.be/vgr8r2IUzZA

TET knockouts cause severe gastrulation defects, but in chimeras, they differentiate (almost) completely normally. Check out how SaiFeng Cheng and Markus Mittnenzweig use that to separate cis from trans effects!

Our work on the functional role of DNMT3A/3B during early development is finally out! Grateful for the opportunity to work with Amos Tanay, gratitude for the collaboration with Aviezer Lifshitz, and thanks to the Tanay group members Weizmann Institute NatureStructMolBiol nature.com/articles/s4159…

Our work on rabbit gastrulation by the Stelzer and Tanay labs is now online! Spicing up the classic evo-devo hourglass theory with temporally dense, comparative analysis of rabbit and mouse gastrulation Cell doi.org/10.1016/j.cell… Weizmann Institute 1/4

New paper from the Tanay lab on longevity is out today in Nature Aging! We employ machine learning to tackle a classical question: What makes some people live long, healthy lives, other than the fact that they are not sick with any chronic disease? nature.com/articles/s4358… (1/17)

Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬 IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable. Nature Communications: nature.com/articles/s4146… Thread 🧵👇 1/