Congratulations to Profs. Assaf Vardi, Steffen Jung, Oren Schuldiner & Yonatan Stelzer of upon being elected as members of EMBO Oren Schuldiner's Lab @TheJungLab @VardiLab

Beyond excited to share our #NewPaper in Cell! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

To all post-docs: The Genome Biology dept EMBL has an Independent faculty position. Fantastic place to set up your lab, great package: core funding, fantastic PhD students, cutting edge core facilities & great colleagues embl.wd103.myworkdayjobs.com/en-US/EMBL/job…

Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬　Shiori Iida Masa A. Shimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗biorxiv.org/cgi/content/sh… (1/3)

Arjun Raj There is a lot of truth to this. The advances in sequencing throughput continue. The one exception might be 3D genomics. 100x coverage of the human 3D genome at nucleosome resolution would require 10^16-17 reads: nature.com/articles/s4158…

Do we need LLMs to predict epigenomes from DNA—or is biophysics enough? 🧬 IceQream (IQ) is a biophysics-based framework that predicts epigenomes with SOTA-level accuracy—and is fully explainable. Nature Communications: nature.com/articles/s4146… Thread 🧵👇 1/

1. Online now in Nature, we present our effort to understand the mechanistic basis of congenital heart defects in children with Down Syndrome. An overview thread below... nature

I am delighted to share that my main PhD project is finally out in Science Magazine! I'm honored to have worked with so many talented colleagues and mentors that guided this journey and provided me an opportunity to contribute research! science.org/doi/10.1126/sc…

Biopsies provide just a single snapshot of the underlying tissue. In our recent work published in nature, we made progress in estimating tissue-level dynamics from a biopsy using spatial proteomics. nature.com/articles/s4158…

On Feb. 4, a Cell study from Westlake University led by Prof. Shang Cai's team revealed that intratumor bacteria influence cancer metastasis and recurrence depending on whether they reside inside or outside cancer cells. Intracellular bacteria activate the cGAS–STING–IL17B

Excited to share VIPerturb-seq! New tech from my lab which aims to improve the cost, data quality, and efficiency of single-cell CRISPR screens so that they are accessible to any lab - even at genome-wide scale Preprint and 🧵 (1/): biorxiv.org/content/10.648…

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in Science Magazine, led by our fantastic graduate student Ziyu Lu from Rockefeller University! science.org/doi/10.1126/sc…

We develop cf-EpiTracing, a new liquid biopsy tl to trace tissue origin and therapy responses using cell-free multimodal chromatin states from as little as 50 ul plasma, now nature. Congrats to Xubin, Xiaoxuan, etc. Big thks to many many collaborators! nature.com/articles/s4158…

🔬Westlake University’s School of Life Sciences is joining forces with Science Magazine /AAAS for a new 10-part online symposium series. Starting March 2026, top scientists worldwide will explore cutting-edge topics in life sciences and biomedicine. 🧵 10 symposia. 10 frontier

A new mechanism for “RNA memory”! 😱 Thrilled to share another crazy paper from the lab (can’t believe we posted 2 in 2 days!), summarizing >10 years of research: Work on transgenerational inheritance of small RNAs in the powerful model organism C. elegans changed how we think

What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.

Excited to see our work in nature! We combined our PIGA workflow & a cost-effective sequencing strategy to build the 1000 Chinese Pangenome (1KCP). We hope this methodology & resource help unlock complex variants in human health. Yifei Wang Duan Zhongqu nature.com/articles/s4158…

Published in nature, a new study by Prof. Jian Yang's (Jian Yang ) team at Westlake University introduces the PIGA workflow—building the largest human pangenome to date, with 1,116 diploid genomes. This leap forward breaks past the small-sample bottleneck, opening the door to a

Great work, congratulations!