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This recently published figure by Sarah Ancheta et al. is very disturbing and should lead to some deep introspection in the single-cell genomics community (I doubt it will). It demonstrates complete disagreement among 5 widely used "RNA velocity" methods 1/

The NVIDIA Healthcare team just made 2 foundation models available as inference microservices. DiffDock, a predictive model for how drug candidates bind with target proteins. And MolMIM for controlled generation of small molecules bit.ly/4fxU3oQ

In 2016, researchers at the University of Adelaide tested Kurt Vonnegut's theory that, "There’s no reason why the simple shapes of stories can’t be fed into computers." They took the emotional arcs of 1300+ novels from Project Gutenberg, turned that into data, used modern tech

New pre-print from our group! Local photo-crosslinking and stiffening of ECM proteins within ex vivo tissues to probe lung epithelial cell function: biorxiv.org/content/10.110… Led by Donia Ahmed & Matt Tan and huge team effort with Baker Lab Rachel L. Zemans Lin Han

Amphiregulin (AREG) expression was elevated in intermediate #alveolar stem cells of mouse fibrotic lungs and idiopathic pulmonary fibrosis patients. An AREG-neutralizing antibody efficiently blocked lung #fibrosis development. 🛡️ Cell Stem Cell | bit.ly/3YLdW5Z

Choosing suitable color palettes for accessible and accurate science figures …rentprotocols.onlinelibrary.wiley.com/doi/10.1002/cp…

🔹Innovative research from the team Penn Medicine: 🐭Two #murine models to show a mechanistic link between #SARS-CoV-2 infection, #AT2 cell biology, and #respiratory failure. Read more: ow.ly/iwJT50T80cA

Happy to share our work examining lung T cell responses during severe pneumonia—including #COVID19: nature.com/articles/s4159…. Huge lift 💪 from The NU SCRIPT Investigators NM Pulmonary and Thoracic Surgery Northwestern Feinberg School of Medicine. Kudos to Nikolay Markov @[email protected] Ziyou Ren & Karolina Senkow 🧵

por los árboles!!!!!

📣 The much-revised manuscript of LIANA+, our all-in-one solution to study cell-cell communication from single-cell, spatial, and multi-omics technologies, is now published in Nature Cell Biology nature.com/articles/s4155…

Luisa Morales-Nebreda, MD (@luismnMD), discusses a recent study she led to explain longer times on ventilators for patients with #pneumonia caused by #COVID19. The study explored T-cells in lungs and how they behave differently in patients with SARS-CoV-2 pneumonia compared to

Granulomas guide researchers to an FDA-approved drug for sarcoidosis. Sati et al. identify type 1 innate lymphoid cells as a biomarker for sarcoidosis and find plerixafor-treated mice develop fewer lung granulomas. Thomas Leung Penn Medicine

Excited to share TxGNN, a model that identifies potential therapies from existing medicines for thousands of diseases. Trained across 17,080 diseases, TxGNN predicts drug candidates for conditions with limited or no treatment options, including rare diseases Nature Medicine

An absolutely bonkers stat from this Nature article on Nobel Prize winners. "702 out of 736 researchers who have won science and economics prizes up to 2023 are part of the same academic family" nature.com/immersive/d415…

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Using a specific TRβ agonist, sobetirome, Henan University - 河南大学 scientists demonstrated that Rβ activation confered AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA. go.nature.com/4gSzzYN

What gets erased when you integrate single cell data, and can you recover it? Finally, we know what happens and how to recover the lost signals. So excited to share CellANOVA, published online today in NBT! go.nature.com/4hZnzW5

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell

Study shows that senescent cells literally sugar-coat themselves to avoid recognition and clearance by the immune system. nature.com/articles/s4358…

Introducing La-Proteina, a generative AI model that creates complete atomistic protein structures together with their amino acid sequences, scalable upto 800 residues. Built by @NVIDIA Research, in collaboration with University of Oxford and Mila - Institut québécois d'IA La-Proteina addresses a key