Hi all, we are looking to add some lab members at various levels like technician, grad student, postdoc, senior scientist. Check out our projects here: gruberlabutsw.org please retweet

Check out our latest preprint bioRxiv led by the newly minted Dr. James T Hagen, PhD 👇 In it, we investigate the peculiar bioenergetic phenotype of AML with the goal of identifying cancer-cell intrinsic mitochondrial physiology potentially actionable to treat the disease.

Needhi Bhalla 💅🏽 I have lately been explicitly saying I’m a basic scientist and proud of it at the end of my talks. I’ve had a couple trainees tell me they were encouraged by that.

Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.110…

Shoutout Nathaniel Snyder & Co for employing their VB5 Stable Isotope Labeling with Essential nutrients in Cell culture (SILEC) method to trace exogenous unlabeled CoA into macrophages. Provides compelling evidence for a mac CoA uptake mechanism. (2/x)

Also: new murine breast cancer model immunotherapy data - nice additive effects of combining T cell checkpoint blockade + i.t. MPLA/CoA (former is clinically approved TLR4 agonist). Now working on a better way to get CoA into tumors to reprogram TAMs... (7/x)

Meet Nathaniel W. Snyder Nathaniel Snyder Winner of the 2024 Chemical Research in Toxicology Young Investigator Award! Read our interview here 🔗 go.acs.org/9HM

Poster sessions are the real reason for conferences.

Dr. Erica Golemis, a trailblazer in cancer research, has been appointed as the Senior Associate Dean of Research. We are so proud to have her outstanding leadership shape the future of research at #TempleMed.

PhD students thinking about academic postdocs-after some exciting grant news, my lab is hiring! We love all things cellular metabolism, and projects are tailored to fit individual interests. Opportunities exist for co-mentorship with other labs. More info: airdlab.com/positions

New from Daniel P Kelly How do SGLT-2 inhibitors work? Some intriguing SGLT2 independent actions in mice with HFrEF Circulation Research ahajournals.org/doi/abs/10.116…

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

Its crazy that the first lab to do inVivo metabolic labeling proteomics by feeding mice heavy isotope AAs called it SILAM when the name Miceotopes was sitting right there

My baby girl came on Monday night and closing the week with a first author paper from Russell Jones ! What a week!! Many thanks to everyone for all the efforts to get this paper out!!

Soooo excited and honored to receive the AACR - Anna D. Barker fellowship that will support my research on uncovering a new link between #metabolism and #epigenetics in #PDAC. Many thanks to my amazing mentors @WellenLab Nathaniel Snyder for making this possible. Stay tuned!!!

📢Thrilled to announce that I will start independent position at Fox Chase Cancer Center Jan 2025 @CEI-FCCC Fox Chase Cancer Center. The Luo lab will study novel #mechanisms controlling stem cell fate choices in normal and diseases. 🧬🔬🐁🩸#RNA #RNAmodifications #HSC #leukemia (1/4)

A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA biorxiv.org/cgi/content/sh… #biorxiv_biochem

Great opportunity for an metabolomics expert and manager to lead the Platform at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen. Thanks for RT! Metabolomics Society Nordic Metabolomics Society @JuliJivanisevic

I am excited to share our new preprint on lactate metabolism! This has been a tremendous effort by my lab, Stavros George Drakos and Rutter Lab to integrate biochemical and physiological data to understand the mechanism of lactate metabolism in the heart. biorxiv.org/content/10.110…. .

Congrats Kate Korobkina et al for our Nature Metabolism paper online now showing that in brown fat—a thermogenic tissue famous for generating vast amounts of acetyl-CoA in mitochondria—cytosolic acetyl-CoA synthesis also matters…ALOT. Find out why here: rdcu.be/dWUqM