In our latest #ClinicalTrialClub webinar, expert speakers, J.J. Kiladjian and Angela Fleischman, discussed the present clinical landscape and its challenges, how to optimize treatment sequencing, and explored ongoing clinical trials and key data.

Thank you for highlighting our work which was a collaborative effort among many UK centres! Non melanoma skin cancers on patients taking Ruxolitinb can behave extremely aggressively and patients and clinicians should be aware and monitor closely!

What novel therapies are under investigation for the treatment of high-risk #MPN ?

Check out our expert video interview with Prithviraj Bose during #ESHMPN2024 to learn more: loom.ly/K5-dT9A
#MPN sm #ESHCONFERENCES #MedicalEducation #MPN Research

#Age -specific induction of mutant #p53 drives clonal hematopoiesis and #AML in adult mice
doi.org/10.1016/j.xcrm…
#CH #aging #leusm

Beauty of serenity.
#kyoto

Favorable outcomes in MDS and oligoblastic AML-MR after reduced-intensity conditioning allogeneic HSCT with PTCY
nature.com/articles/s4140…
Bone Marrow Transplantation The EBMT Trainee Committee #BMTsm #MDSsm #leusm

Context-dependent role of trisomy 6 in myelodysplastic neoplasms and acute myeloid leukemia: a multi-omics analysis | fantastic job by ⁦Hussein M. Awada⁩ ⁦Valeria Visconte⁩ and all the MaciejewskiLab team of ⁦Cleveland Clinic⁩ nature.com/articles/s4137…

Postinduction qRT-PCR MRD+ NPM1 AML patients benefit from allogeneic in CR1

- 3 yr OS with CR1-allo vs without: 61% vs 24%; HR 0.39, P < .001)

- But no benefit for MRD− patients (irrespective of FLT3-ITD)
doi.org/10.1182/blood.…

#leusm #BMTsm Mike Dennis The EBMT Trainee Committee

✅Changes in IPSS-R between dx & HSCT did not affect HSCT outcome if no prior therapy was applied.
✅Downstaging IPSS-R by chemotherapy improved HSCT outcome.
#MDSsm #BMTsm Blood Journal DrDonalMcLornan The EBMT Trainee Committee
doi.org/10.1182/blood.…

#EHA2024 is an opportunity for researchers to learn, connect, & grow. With a full-day YoungEHA Research Meeting program with talks by early-career professionals & networking sessions, this is your opportunity to connect with our community.

Register now: eha.fyi/EHA2024_regist…

One of the Best Papers I have read so far
If your CMLs are failing their molecular milestones and you are sweating buckets - well fear not - things might not be as bad as you think !
Have a read 👇👇
Thanks Your A. Emre Eşkazan, MD 🩸🔬 for sending me this
#MedTwitter
nature.com/articles/s4137…

Honored to be co-senior author on this effort led by Dr Della Porta combining GenoMed and Moffitt database. Moffitt Cancer Center Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of AHSCT in Pts With MDS | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

Excellent international collaboration led by GenoMed4All # Dr. Della Porta on using IPSS-M Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes #MDSsm | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

Fresh off the press🎉🎉Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients With Myelodysplastic Syndromes | Journal of Clinical Oncology ascopubs.org/doi/pdf/10.120…

A prospective study of posttransplant cyclophosphamide for unrelated donor peripheral blood stem cell transplant with special attention to graft content and the impact of a higher γδ T cell dose eJHaem Journal
onlinelibrary.wiley.com/doi/full/10.11…

Notre Dame de Paris. Nov 2018.

IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation ow.ly/kFn150Rv5Mo #myeloidneoplasia

We're thrilled to announce our brand new #singlecell study of clonal dynamics from #MPN chronic phase to #AML evolution, published on AmericanJournalofHematology in collaboration with Dmsc_unifi and Humanitas University! 🎈🎈
onlinelibrary.wiley.com/doi/full/10.10…

#Autoimmune #myelofibrosis : A Mayo Clinic series of 22 patients
doi.org/10.1111/bjh.19…
#MPNsm

Which #MDSsm patients are most likely to have UBA1 mutations associated with #VEXAS syndrome?

Our study now out in Blood Journal: Molecular and clinical presentation of UBA1-mutated MDS by Elli Papaemmanuil, PhD, Elsa Bernard, Maria Creignou, David Beck, MDS IWG-PM & MDS Foundation