Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!

Looking for a postdoc or staff scientist position to study metabolism and the systemic effects of cancer? Enjoy sun, beaches, hiking trails, sushi and tacos? We have multiple positions open. Join us today! sbpdiscovery.hrmdirect.com/employment/job… sbpdiscovery.hrmdirect.com/employment/job…

Please re-post and share with students and teachers in LA area, #UCLAPOP hands-on research opportunity for high school students interested in careers in science Baljit Khakh David Geffen School of Medicine at UCLA UCLA UCLAAnes
uclahealth.org/news/high-scho…

Great application of DNA language models to prokaryotic genomes. Excellent impactful application use cases of the model. Congrats to all the authors!

But a quick answer to the first question. No - DNA is not all you need. 1/

Our latest in nature:

Convergence of coronary artery disease genes on endothelial cell programs

nature.com/articles/s4158…

Incredible work led by Gavin Schnitzler and Helen Kang — a long-standing partnership between our lab and Raj Gupta

My comments below:

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Please share: We are seeking new postdoctoral fellows. NIH is a fabulous place to do science and I'd like to think our group is doing exciting work in somatosensation, Interoception and pain.
training.nih.gov/jobs/pdf-04012…
nccih.nih.gov/about/jobs/pos…

Want to infer causal regulatory changes from scRNA-seq/spatial data? We combined Perturb-seq with Parse Biosciences + Ultima Genomics to systematically perturb signaling regulators across six cell lines and learn their downstream targets. Preprint and data at biorxiv.org/cgi/content/sh…

I’m hiring a postdoc and SRA for my new lab at Sanford Burnham Prebys in San Diego, CA! Are you passionate about dissecting the interplay between the immune system and cancer? Apply here 👇🏻
sbpdiscovery.org/about/careers

Learn more about what we do at:
kerstenlab.com

Please share!!

Having coffee with newest Jr faculty in San Diego! Sanjeev Ranade was a graduate student in my lab and is now faculty at neighboring Sanford Burnham Prebys. He is studying cardiac development.

New preprint! So excited to present CHOIR, a new clustering method for single-cell data that evaluates whether clusters represent statistically distinct cell populations. CHOIR works with both single- and multi-omic data of any type. Check it out! biorxiv.org/content/10.110…

A new Nature paper by Emma Farley and colleagues reminds us again that we have hardly scratched the surface of exploring the enigmatic universe of noncoding variants. A weekend read.

Lim, Solvason, Ryan, et al. Nature
nature.com/articles/s4158…

I’ve said many times…

I wrote down my rules on how to Science. I hope you find it useful!

A few thoughts on the recent comparison paper for imaging-based #spatialtranscriptomics (iST) methods from the Rahul Satija:
biorxiv.org/content/10.110…

We compared six commercial + academic multiplexed in-situ gene expression profiling technologies. Check out our preprint, led by Austin Hartman.
Takeaway when evaluating spatial tech: consider both sensitivity and specificity!
biorxiv.org/cgi/content/sh…

With the start of 2024, I say goodbye to my beloved SF to start a new adventure in SD Sanford Burnham Prebys . Lots of love for the amazing people around me who have supported me through this move!! ❤️

In the process of working on this manuscript I have developed many modular tools at the intersection of single-cell sequencing and functional genomics. Because this work has many of them I'd like to introduce them and give a short blurb on each

My autobiography is now published on the The Nobel Prize website. It covers both my personal and professional life, highlighting the decisions and events that have had the biggest impact. I appreciate the opportunity to tell my story. Hope you enjoy reading it
nobelprize.org/prizes/medicin…

An encyclopedia of enhancer-gene regulatory interactions in the human genome

twitter.com/argschwind/sta…

Very proud—4 years in the making, huge team effort.

This is a paper where the author list cannot convey everyone's incredible contributions.

My holiday highlights below:

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Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…

I'm incredibly excited to share our most recent work: 'Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis'

doi.org/10.1101/2023.1…