A systematic review presents evidence that psychosocial interventions for adults with schizophrenia improve functional outcomes, quality of life, and core illness symptoms. Read more: bit.ly/3lq6ZlN

The opening keynote session of the #CannabinoidGRC is in full steam, so great to see science in person BryanRoth Hurd Laboratory of Addiction Neuroscience @Katonalab

A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo #PKU go.nature.com/31UuKfy

Just in time before the holidays! Congrats András Tóth for your presentation DrGPCR Summit! Enjoy the goodies! #gpcr #drgpcr

Can we identify common mechanisms behind antiviral drug effects by analysing drug and SARS-CoV-2 induced gene expression signatures? Our latest project, led by Szilvia Barsi is now published in PLOS Comp Biol: journals.plos.org/ploscompbiol/a…

We congratulate our colleague, Péter Ábrányi-Balogh, for his recent achievements: in addition to being promoted to senior research fellow, Péter was recently awarded with the Zemplén Géza Prize for his work in organic and medicinal chemistry! 👏👏

Excited to share our recent review in Frontiers in Systems Biology, which highlights the use of perturbation gene expression profiles to connect causal perturbations to gene expression changes for drug discovery applications. frontiersin.org/articles/10.33…

A few years ago, I conducted an experiment with an endocytosis inhibitor that completely changed my understanding of signaling bias. We dove deeper into the spatiotemporal aspects of bias. See our biorxiv preprint for more: biorxiv.org/cgi/content/sh… #GPCR #signaling #pharmacology

I had read a paper on GPCRs and arrestins in Journal of Biological Chemistry several years ago and sent a congratulatory note to the authors. I met the 1st author in Budapest last week and he mentioned how motivating that email was to him and inspired him to continue in this field. #Win#For#Science.

DSI is a form of synaptic plasticity mediated by endocannabinoids (eCBs). With Linlin Fan, we demonstrated in vivo that place cell activity triggers eCB signals affecting GABAergic inputs; and that cannabinoid receptors modulate place cell tuning. science.org/doi/10.1126/sc…

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins dlvr.it/T71kbZ

Congratulations to @Katonalab and colleagues on their new article! They combine #Electrophysiology and correlative #Confocal and #SuperResolution #Microscopy to identify and study single synapses, providing insights into retrograde cannabinoid signaling: bit.ly/4eaXCB0

Research reveals how location within cells can influence the phenomenon of biased signaling, a Focus dissects recent research spotlighting a potential target for cognitive enhancement, and more in the new issue of #ScienceSignaling. scim.ag/7so

A new paper shows that the #endocytosis of #GPCRs such as AT1R can influence biased signaling through #BetaArrestin, suggesting the efficacy of beta-arrestin-binding ligands depends on spatial location as much as on receptor conformation. Semmelweis University scim.ag/7th

Astonishingly, differences in beta-arrestin recruitment almost completely disappeared without endocytosis. Since beta-arrestins form stable interaction with AT1R, even at endosomes, we speculated that agonist-specific differences occur endosomally.

Our perspectives on the various aspects of bias in GPCR function, with a special focus on their relevance to the kidney, have been published in Nature Reviews Nephrology. nature.com/articles/s4158…

'These findings imply that vascular anatomy sets a resolution limit on functional imaging signals... individual blood vessels inaccurately report neuronal activity in their immediate vicinity ...' nature.com/articles/s4159…

Read our Nature Portfolio Behind the Paper blog post on our recent work on photoaffinity-based fragment libraries here: communities.springernature.com/posts/photorea…

Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs - now published in Chemical Science pubs.rsc.org/en/content/art…

Wow!! nature.com/articles/s4146…