GLP-1 analogues that induce prolonged signaling relative to GLP-1 Patrick M Sexton biorxiv.org/content/10.110…

Sending people to prison just for possessing marijuana has upended too many lives and incarcerated people for conduct that many states no longer prohibit.

It’s time that we right these wrongs.

Im trialling an online peer support group for people who have experienced difficulties after psychedelics, Sunday 28th at 6pm UK / 1pm ET. Not a therapy group, just peer support. Let me know if you'd like to attend - limited places as it's the first one but we aim to do monthly.

Could GLP-1 receptor agonists like semaglutide treat addiction, Alzheimer disease, and other conditions? Animal and human studies have uncovered a host of possible uses for drugs that stimulate the ubiquitous GLP-1 receptors. ja.ma/3JoAHnx

Nature research paper: Promiscuous G-protein activation by the calcium-sensing receptor go.nature.com/3Jq3fgp

Microscopy structures reveal mechanism behind bitter taste: chemistryworld.com/news/microscop…

🚨 Breaking: Israel's attack destroyed the entire air defense systems of Iran's nuclear facilities

How does a mixed-valent diiron oxygenase help in the #biosynthesis of a copper chelator?

Rosenzweig Lab, Hoffman and colleagues Northwestern use ENDOR to look at substrate binding, revealing the initial steps toward methanobactin.

pubs.acs.org/doi/10.1021/ac…

#bioinorganic

datawrapper.dwcdn.net/3mUpM/1/

Drug development programs with support from human genetics are 2-3 fold more successful.

3 take-aways:
1. Effect size of genetic association doesn't matter.
2. Indications with biomarkers are more successful
3. Less helpful for symptoms of disease.

nature.com/articles/s4158…

Do you have difficulty to describe you research in a few minutes to lay audience? Join this webinar to get tips from 3 PhD students who won the 3 Minute Thesis competition at HUPO2023 in Busan. Human Proteome #HUPOECR #TeamMassSpec

New paper alert 🥳A team from the Monash Institute of Pharmaceutical Sciences node recently solved the #CryoEM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein - read more here: pubs.acs.org/doi/10.1021/ac…
ARC ARC CCeMMP Jason Cao #GPCR #drugdiscovery #migraine

Great article, 'Inside Boston’s Psychedelic Revolution'
#psychedelics
bostonmagazine.com/news/2024/01/2…

Molecular basis of proton-sensing by G protein-coupled receptors biorxiv.org/cgi/content/sh… #bioRxiv

The range of functional selectivity of these D1R agonists will provide valuable tools to further investigate D1R signaling, trafficking and therapeutic potential.
biorxiv.org/content/10.110…

The range of functional selectivity of these D1R agonists will provide valuable tools to further investigate D1R signaling, trafficking and therapeutic potential.
biorxiv.org/content/10.110…

Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening pubmed.ncbi.nlm.nih.gov/38619283/

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need | Science www-science-org.libproxy.lib.unc.edu/doi/10.1126/sc…

UNC System board committee approves policy gutting DEI. Students say they were kept out. Admin positions & offices dedicated to DEI are likely to be eliminated at all North Carolina public universities. (Via Korie Dean & Luciana Perez Uribe Guinassi) #ncpol #nced newsobserver.com/news/local/edu…