I am thrilled to share my preprint with #AlexisCaulier and others in Vijay Sankaran lab, showing how systematic mapping of transcription factor networks in human hematopoiesis massively enriches for heritability of blood cell phenotypes! biorxiv.org/content/10.110…. A thread below (1/n)

came across a gem of a channel for learning gpu programming, covers > kernel basics > code simple neural network by just using cuda > cuda memory > performance factors in GPU wonder why these type channels and videos are so underappreciated

How bad is it for a kinase to phosphorylate the wrong protein? David Bradley and Alexander Hogrebe, PhD tried to measure that systematically. See their results now online! Collaboration with Judit Villen funded by HFSP! embopress.org/doi/full/10.10…

If Republicans really want to send the abortion issue "back to the states," then why are all these red states trying to take it off the ballot? 🤔

Rasmus Kirkegaard More products are generally better I think. The main question for a meaningful chunk of ONT userbase is, how much? Financial and logistical accessibility is a substantial advantage driving the platform, otherwise everyone would have just bought pacbio five years ago.

High-coverage, massively parallel sequencing of single-cell genomes with CAP-seq biorxiv.org/cgi/content/sh… #biorxiv_genomic

I don’t want to take anything away from the excitement around amycretin (data is indeed impressive) but please note that at 100mg/day (2 x 50mg pills) you’re looking at having to make 3.65 tons of the peptide for every 100K annual Rx. #EASD2024

We need a Gordon Ramsay's Kitchen Nightmares for science. Gordon going into struggling labs, revealing the horrors lurking in fridges and file drawers, calling a postdoc a donkey.

In searching for material for my class on Indigenous science, I was happy to see that this Science article highlighted specifically the Native BioData Consortium (NativeBio Data Consortium) as an exemplar for serving as a Tribal institution that empowers Indigenous data governance and promotes

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Really proud to co-author this paper on the genetic history of the Rapa Nui people. The genomes of 15 Rapa Nui reveal admixture with ancient South Americans took place soon after first landfall w. no later drop in gen. diversity consistent with 'ecocide'. nature.com/articles/s4158…

CAP-seq: High-coverage, massively parallel sequencing of single-cell genomes biorxiv.org/content/10.110…

Scaling up for success: from bioactive natural products to new medicines - Natural Product Reports (RSC Publishing) - from Novartis pubs.rsc.org/en/content/art…

We used PaperQA2 to extract claims from papers and then see if they're contradicted anywhere in literature. This task is time consuming for humans, but we were able to use this for hundreds of papers to look for trends in disagreement in fields, decades, and journals.

A widespread form of regulatory capture that blocks smaller competing companies. Regulatory agencies need to work MUCH more quickly for ALL applicants

Multi-pass, single-molecule nanopore reading of long protein strands | Nature nature.com/articles/s4158…

If bispecific T-cell engagers are BiTEs then when you generalize it to multi specific do they become…MuTEs? MiTEs?

My new novel, Polostan, goes on sale October 15. Signed copies are available for preorder from @BNbuzz and Books-A-Million. B&N:  bit.ly/3TmSlxg BAM: bit.ly/4ghh67T

Dear Kremiln, Tough shit.