Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells nature.com/articles/s4146…

Today in @natchembio we share a new strategy to design fully synthetic “artificial” bZIP family transcription factors that directly block DNA binding of HIF1a and XBP1 to inhibit hypoxia-dependent oncogenic signaling in cells and in vivo. 1/n  nature.com/articles/s4158…

Excited to see our story showing that the #stressresponse regulator #HSF1 modulates NK cell anti-tumour immunity out in ⁦Nature Cell Biology⁩. Thanks to fantastic work with ⁦Nikos Kourtis⁩ ⁦Iannis Aifantis⁩ and team ⁦NYU Langone Health⁩ 🧵👇 nature.com/articles/s4155…

Aldehydes alter TGF-β signaling and induce obesity and cancer dlvr.it/TCjQr3

Very excited to share our latest paper out today Nature Metabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies. dlvr.it/TCjPl6

Thank you EACR for highlighting our work on breast cancer bone metastasis! New immunotherapy combinations are the way to combat #metastasis. Lea Monteran Cancer Discovery magazine.eacr.org/highlights-in-…

Super happy to share that our paper is published in nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥CCB_VIB_KUL Department of Oncology - KU Leuven The Netherlands Cancer Institute Van Rheenen Lab Benjamin Simons

What slows or speeds brain aging? This is just 1 of 10 recent papers in today's nature nature.com/articles/d4158… This one along with the others are reviewed in the new Ground Truths, link in my profile

Exercise-induced ROS production activates multiple signaling pathways that are responsible for the beneficial effects of #exercise. 📚"Redox Signaling in Widespread Health Benefits of Exercise" doi.org/10.1089/ars.20…

In a study in nature, researchers demonstrate the role of sex hormones in regulating the immune system. This knowledge explains differences between men and women and can be used to develop new immunological medications. Research by Petter Brodin et al. news.ki.se/new-research-e…

Excellent review from mariangela russo Bardelli Lab discussing our current understanding of drug-tolerant persister cells in cancer. nature.com/articles/s4156…

Extremely happy to share our last article by our Marta Mascaraque et al. on the role of fatty acid metabolism in PDAC recently published in Journal of Translational Medicine!! Check it out: rdcu.be/dSi2v Check also our last post to know more: cscmetabolism.com/2024/09/06/new…

So excited to share this enormous piece of work with you! Led by lacroix🅿️a🅿️i while he was here at Johns Hopkins BMB (he’s now an assistant professor Fox Chase Cancer Center ). A thread!! cell.com/cell/abstract/…

Happy to share that our paper led by the amazing and now assist prof Clyde Campbell is available Nature Communications! 🎊🎉🍾🥳 nature.com/articles/s4146…

Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy: Cell 👇🏼 Must read👇🏼 by⁦⁦Ashi_W⁩ and team, amazing work 👇🏼 cell.com/cell/abstract/…

TGF-β and RAS jointly unmask primed enhancers to drive metastasis Cell MassagueLab cell.com/cell/fulltext/…

Our article in Trends in Cancer Trends in Cancer led by Claudia Galassi Lorenzo Galluzzi Lorenzo Galluzzi Weill Cornell Medicine and Ilio Vitale explaining how aberrant #epigenetic setting such as DNA #methylation and #histone modifications promote #immune escape in #cancer #stem cells

Classifying cancer-associated fibroblasts—The good, the bad, and the target: Cancer Cell cell.com/cancer-cell/fu…

The Marcato Lab and collaborators found that ALDH1A3 regulates these cancer-promoting processes and the abundance of the two distinct breast CSC populations defined by high ALDH activity and CD24−CD44+ cell surface expression. 👉 go.nature.com/3zbTsZP

In an National Cancer Institute funded study, DeBerardinis Lab Children’s Research Institute at UT Southwestern et al. found that electron transport chain inhibition remodels cellular purine metabolism and revealed a potential therapeutic vulnerability in tumors with low mitochondrial respiration Cell Metabolism cell.com/cell-metabolis….