Very interesting paper from Ben-Sahra Lab - and since I’m at the SQE symposium at Northwestern today, I get to hear him talk about this in about an hour. Great timing! -RJD

I'm happy to share my first paper from the DeBerardinis Lab, a focus piece highlighting work from Papagiannakopoulos Lab and recent advancements in efforts to target glutamine metabolism in cancer.

Glutamine antagonists may KEAP lung cancer in check | Science Advances science.org/doi/10.1126/sc…

The Green Center for Reproductive Biology Sciences, Children’s Research Institute at UT Southwestern, and UTSW_PROVIDES cordially invite you to our next seminar, which will be led by Dr. Kathryn E. Wellen, a Professor of Cancer Biology at the University of Pennsylvania. 

Seminar: 'Acetyl-CoA metabolism in gene regulation and tissue homeostasis'

Interesting new paper from Izumi lab (Kosuke Izumi, MD, PhD) @UTSWNews UT Southwestern Rare Disease Center of Excellence UT Southwestern Pediatrics expanding the clinical spectrum and developmental consequences of variation in RNA Polymerase III function. -RJD

My daughter’s utter amazement at the dome of the Pantheon in Rome. Fascinating thread below about this marvel of engineering. -RJD

Can’t wait! -RJD

Excited to share our recent work on the surprising effects caused by loss of malonyl-CoA synthesis in liver. Outstanding work by Stanislaw Deja and the whole lab. Thank you Cell Metabolism, Immortal Amber and the reviewers that made the paper better!

authors.elsevier.com/sd/article/S15…

.NORD day at the Zoo - @UTSWNews UT Southwestern Rare Disease Center of Excellence UT Southwestern Pediatrics -RJD

A multi-institutional preclinical resource of profiling data released on Feb 29 that should help the #LungCancer field “leap” forward.
A Lung Cancer Mouse Model Database
biorxiv.org/content/10.110…
Preprint from Trudy G Oliver, PhD Charlie Rudin Monte Winslow's Lab DeBerardinis Lab John Minna and colleagues

#RareDiseaseDay2024 : “think of zebras when you hear hoofbeats.” Some rare diseases can already be treated, and the #GMDP team Children’s Research Institute at UT Southwestern wants to cure even more. Thanks NORD NORD and the Rare Disease CoE @UTSWNews for all you do for these patients. -RJD

via @NYTimes - Yes, I’m sad about this, OK? -RJD nytimes.com/2024/02/23/nyr…

This is what it looks like when someone with power and responsibility has spent *zero* time thinking about the complexities of an issue. He has no clue how to answer. Thanks to the reporters for asking the right questions, even obvious ones. Please keep it up. -RJD

1/ Excited to share our new paper with Sihan Wu 吴思涵 UTSW Simmons Cancer Center Children’s Research Institute at UT Southwestern and Michael Lawrence Mass General Research Institute, now online Cancer Discovery. Led by Shreoshi Pal Choudhuri, we found that ecDNAs with MYC paralogs drive acquired cross-resistance in small cell lung cancer #SCLC
aacrjournals.org/cancerdiscover…

Beautiful paper from Ron Kopito, Roland Beckmann & colleagues providing structural and functional insights into the role of UFMylation in recycling 60S ribosomal subunits released following ribosome stalling and quality control at ER translocons. 🤩nature.com/articles/s4158…

'I really enjoyed talking about Atavistik, allosteric drug discovery, and the future of drug discovery with the BIOS Podcast alongside Marion Dorsch. Check it out!' -JR U of Utah Dept of Biochemistry HHMI NEWS Atavistik Bio

Great news Gerta Hoxhaj Lab Children’s Research Institute at UT Southwestern @UTSWNews! Congratulations Gerta and the rest of the awardees. -RJD