I just learned Prof. PC Huang has died. He was a brilliant scientist, world famous for his work on metallothionein-encoding genes, which are inducible by metals and other stress conditions. Also a great mentor and advisor, and wonderful colleague. Really sad news.

Our paper studying drug responses in liver cancer with pharmacoproteomics is now out in Cell Systems: cell.com/cell-systems/f…. Great work led by Martin Golkowski with awesome collaboration from Maly and Yeung labs University of Washington and Taran Gujral Fred Hutch Cancer Center.

I wanted to discuss the degree to which population immunity may be contributing to curbing #COVID19 in Florida, Arizona and Texas, where recent surges have resulted in substantial epidemics. 1/16

Congratulations to Murshid Alam and team (including the Finn Group GT (Bio)chemistry) for their findings in ACS Nano. Conjugates that target DC-SIGN on dendritic cells through pH-stable ligands afford cellular immunity: pubs.acs.org/doi/abs/10.102…

Lots of recent discussion about #SARSCoV2 re-infections, with 2 pre-prints describing possible examples. To contextualize these re-infections, I'd like to discuss the following papers, which document same-season re-infection with influenza, and re-infection with measles (1/6).

Our new eLife paper is online: "PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response". The anti-tumor activities of PARP1 inhibitors can be ascribed, at least in part, to their immunomodulatory functions. elifesciences.org/articles/60637

Instead of calling microbes 'pathogens', 'opportunists', 'pathobionts', etc. I prefer to think that all microbes have some pathogenic potential in some host and this can be easily calculated, which frees you from the messy lexicon. pubmed.ncbi.nlm.nih.gov/28251180/

Excited to share our work PNASNews with the Johnson lab UAB, where @JHSPHBMB PhD graduate Robert Lyle McPherson discovered that a conserved activity to remove ADP-ribosylation is present in bat, from which many coronaviruses (e.g., SARS-CoV-2) originate. pnas.org/content/118/2/…

Do you know it is possible to develop #COVID19 drug besides polymerase or protease inhibitors? And this potential drug target is conserved in all human and animal coronaviruses as well as all SARS-CoV-2 variants (e.g., Delta and Omicron)... [Hot off the press] 🧵 below: (1/7)

Very excited to share our work at #ACSSpring2022 this afternoon! Interested in hearing about human lectin selectivity for gut microbiota? Stop by the Hilton Sapphire K/L at 3:30 PM

Lectin-Seq: a method to profile lectin-microbe interactions in native communities biorxiv.org/cgi/content/sh… #bioRxiv

Robert Lyle McPherson and Christine Isabella, Ph.D. headed up a team that explored the specificity of human lectins for human commensals. So fortunate to have such talented researchers in the Kiessling Group and amazing collaborators in the Xavier Lab Eric Alm groups. #glycotime #microbiome

So excited to finally have my PhD work shared with the world! Major shoutout to Robert Lyle McPherson and Laura Kiessling and all of our incredible collaborators. This was an amazing effort by all to better understand how lectins ID microbes in the gut!

Check out the latest work from Laura Kiessling and the Kiessling Group, “Lectin-Seq: A method to profile lectin-microbe interactions in native communities", recently published in Science Advances! chemistry.mit.edu/chemistry-news…

I want to link to the fantastic coworkers (on twitter) that carried out the study Robert Lyle McPherson Christine Isabella, Ph.D. Rebecca Walker dallissergio @sunhee_bae_ Darryl Wesener Anthony Gaca mel halim Amanda Dugan Mike Wuo Soumi Ghosh Eric Alm Xavier Lab #glycotime

Thrilled to see this work out in its final form! Congrats to ALL the co-authors involved in this work with a special shout-out to Christine Isabella, Ph.D. and Laura Kiessling