Pathologists, beware that infectious mononucleosis can mimic DLBCL! Be careful. #pathology #hemepath #PathTwitter

nature.com/articles/modpa…

Exciting prelim results from our trial of Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma! Great cross disciplinary collaboration between cell therapy, neuro-onc and neuro-surgery. Mass General Cancer Center Dr Marcela Maus Bryan D. Choi MD PhD!

We identify the first mutation specific to myxofibrosarcoma, AXL W451C, and show that it results in dimerization and constitutive activation of the AXL receptor tyrosine kinase.

journals.lww.com/ajsp/fulltext/…

Angioimmunoblastic T-cell lymphoma demonstrating CD21+ extrafollicular follicular dendritic cell meshworks that envelop high endothelial venules. Tumor cells are highlighted by CD4.

Pathologists! Check out this case of Dermatopathic lymphadenopathy (DL). Lots of Langerhans cells (LC), but it’s not LC histiocytosis, because the LC are in paracortex (not sinuses), they have a dendritic configuration, are MUM1+, and melanin is present. See PMID 35877199.

Pathologists, Heme Oncologists!
Check out this publication on B-cell lymphomas, open issues for future research #WHO #Lymphoma .
doi.org/10.1002/path.6…

I once listened to Todd Kelley formerly of ARUP talk on how it took two years to work through FDA approval on a simple, single gene PCR test. I can’t even imagine how detrimental this regulation would be for patient care. Due by tomorrow, don’t wait!

Pathologists! Check out these needle cores from patient with B symptoms & diffuse LAD. Our Dx is DLBCL, anaplastic subtype, which often shows sinusoidal involvement and CD30 expression. IHC highlights neoplastic cells in sinuses.
#lymphoma #hemepath

What is this, and what is it caused by?

#pathology #pulmpath

Acute Leukemia = more than 20% blasts or which translocation?
A) inv(16) / CBFB-MYH11
B) t(15;17) / PML-RARA
C) t(8;21) / RUNX1-RUNX1T1
D) All of the above
#hemepath #pathtwitter #pathology #pathresidents
🖼️©️Sarah M. Kelting, MD Lucas Massoth, M.D. غيداء طلال بصفر🇸🇦 @jake_Bledsoe David Steensma, MD

Stomach biopsies from adult.

One of those impossible cases without a good history...

#GIpath #pathology

Large B-cell lymphoma in young patient + in Waldeyer ring + MUM1 & BCL6 co-expression by IHC➡️Think about large B-cell lymphoma with IRF4 rearrangement

These typically dont have starry sky pattern, unlike the variant case illustrated below #hemepath #lymsm #PathTwitter #surgpath

Follicular lymphoma with Hodgkin like cells, see here CD30 and PAX5. EBER negative, CD20 positive in part of the cells, CD15 negative. No inflammatory cells background.

So happy to see this work published! Really thoughtful genomic analysis of clinical samples to discover UV radiation as a potential contributor to malignant transformation in BPDCN. Congrats, Gabe Griffin Andy Lane Peter van Galen volker hovestadt 🧬, and others!
nature.com/articles/s4158…

Touch preparation of mantle cell lymphoma involving lymph node.

Note the angulated nuclear contours of the lymphoma cells and presence of an epithelioid histiocyte, typical features of this lymphoma.

can't beat🧐🔬 #beautyinb9 in a pelvic LN done during radical prostatectomy:

▶️intranodal capillary hemangioma

Bone marrow biopsy of chronic myeloid leukemia (CML) demonstrating increased layers of immature granulocytes around trabecular bone.

BCR-ABL p210 isoform: most common
p190: a/w⬆️monocytes
p230: a/w prominent neutrophilic maturation, thrombocytosis

Lucas Massoth, M.D. Kikuchi was my first thought. Here are the Ki67, Granzyme B and EBER. Acute IM!

Blood vessel radially penetrating a germinal center in hyaline vascular Castleman disease ('lollipop' sign).

What medication is responsible for these bone marrow findings? #hemepath #pathology