The impact of mRNA poly(A) tail length on eukaryotic translation stages doi.org/10.1093/nar/gk…

Meet the newest LSI and UMCDB faculty member! As a @Umich assistant professor, Herman Fung will use advanced microscopy techniques to investigate the dynamic organization of DNA within cells. Learn more about the evolution of his scientific career and plans for his research at

Well this was unexpected! We found that TDP-43 forms heteromeric amyloid filaments with a second protein, annexin A11, in the neurodegenerative disease FTLD-TDP Type C. Read the preprint here: biorxiv.org/content/10.110…

📍our #Neuroscience 2024 Meeting Collaborative teams, patient-led rare disease organizations and research teams came together to discuss their work to advance our understanding of the fundamental biology underlying rare diseases.

Excited to join the HHMI NEWS community - made possible by talented lab members, current and former, and amazing colleagues at Harvard Med Cell Bio and beyond!

Ribosomal protein (rpl40) methylation regulates mRNA translation critical for gastric cancer opening new therapies. Congrats to all! nature.com/articles/s4158…

Big congrats to our newly minted Ph.D. candidates, Brenna and Suada!

Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! nature.com/articles/s4158… We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. Lori Passmore David Rueda

It's a very special day for me. I am so excited and grateful for this opportunity. My lab will study the role of mRNA translation in human immunity. Reach out if you're interested to join us. Gene Center Munich Universität München

Ever wonder if stress granules are intrinsically good or bad in neurodegeneration? Our new paper uses a unique tool to address this question: an alphavirus protein that blocks dimerization of G3BP but does not impact global protein translation. academic.oup.com/nar/article/do…

Here is a short summary of our new paper, describing how protons shape AMPA receptor conformation, kinetics and synaptic location: nature.com/articles/s4159…

I am very proud of the superstar postdoc Haojun Yang, who discovered how to translation control underlying fasting and ketogenic diet in health and cancer. nature.com/articles/s4158…

OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress | Nature Communications nature.com/articles/s4146…

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in nature rdcu.be/dRAQY collab with Deuerling Lab Shu-ou Shan Caltech Swiss National Science Foundation European Research Council (ERC) ETH Zurich

Can ageing be stopped? Nobel laureate Venki Ramakrishnan joins us to talk about his book Why We Die: The New Science of Ageing and the Quest for Immortality. go.nature.com/3AB0yaJ

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Pre-print alert: New insights into the dual ribosomal system in zebrafish. Maternal & somatic ribosomes can form 'hybrid' ribosomes in embryos, and maternal ribosomes are produced in the germline likely throughout the life of the fish. Great collaboration with the Calo Lab!

Paper alert from Iwasaki lab on Nature Communications! We elucidated that eIF4A inhibitor DMDA-PatA selectively represses the translation of mRNA with GNG motif. Congrats, Saito-kun and the team! nature.com/articles/s4146…

Our first study in a new repeat expansion disorder: CANVAS. Connor Maltby used patient iPSNs to define how this non-reference AAGGG repeat impacts neuronal function. He finds a novel role for the repeat in disease that is independent of RFC1 function science.org/doi/10.1126/sc…