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How does the human #ribosome machinery select an open reading frame on mRNA for translation? Check out our #cryoEM work NatureStructMolBiol: rdcu.be/dUbMg Thanks to all involved - most of all first author Valentyn Petrychenko and our collaborators from the Rodnina lab MPI for Multidisciplinary Sciences. 1/5

Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX

Rockefeller's Steve L. Bonilla is developing integrative structural biology methods to visualize dynamic RNA 3D structures and understand how they regulate the life cycles of RNA viruses. #HispanicHeritageMonth

If you are interested in RNA regulation, translational control, cancer progression, and/or therapy resistance... (+cookies&Shenanigans): The Conn Lab is #HiringNow for Postdoc and senior research positions Penn Medicine full description link in thread

Part 1 of our venture into the world of alternative translation-linked proteoforms! (Now Dr) Paul Lee, Yu Sun, along w/Alexa Soares and others in Marina Picciotto lab found that alternative TIS pairs change the localization and functions of synaptic organizers! authors.elsevier.com/a/1jpc73vVUPRm…

Looking back a week ... enjoyed exciting science and great fun with #UMichBiolChem family at our annual retreat in Ohio. Stay tuned - lots to come from this crowd. U-M Medical School Research Michigan Research

St. Jude names M. Madan Babu, PhD, as Chief Data Scientist. He’ll lead the new Office of Data Science, advancing biomedical research with 115 new roles. His work will help integrate vast datasets and improve patient care. #DataScience #BiomedicalResearch ow.ly/gQbN50TAASu

Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to Sven Dorkenwald and Philipp Schlegel, first authors of the connectome papers, Murthy Lab Sebastian Seung for establishing #flywire to make this possible and Davi Bock for birthing this dataset.

covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting (Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)

I look forward to hosting Mitch Guttman from Caltech for a seminar at the UMLifeSciences. #RNA UMich RNA Center 〽️🧬

Happy to share our little discovery with Simone Mattei team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out Nature Communications! A collaboration between @medicineUVA, @EMBL, EMBL Imaging Centre, MEMC. Congrats to all authors! nature.com/articles/s4146…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. Max Planck Institute of Biochemistry (MPIB) 👇👇👇

🚨We’re excited to feature Prof. Daniel N Wilson, a leading structural and molecular biology expert, at the New Techniques—Novel Insights session of #AdvMicro2025 👩‍🔬🧫! Discover cutting-edge insights into ribosome-targeting antibiotics and the development of new antimicrobials.

Winning the The Nobel Prize is the honour of a lifetime and the realisation of a lifelong dream - it still hasn’t really sunk in yet. With AlphaFold2 we cracked the 50-year grand challenge of protein structure prediction: predicting the 3D structure of a protein purely from its

I am looking for a highly talented postdoc to join my lab to study ATP-dependent AAA machines using structural biology, biochemistry, and mass spectrometry. Please apply through the following link: bit.ly/4haSZID For more information, visit: sites.wustl.edu/ghanbarpour/

Now out in peer-reviewed format at Nature Chemical Biology …rdcu.be/dXhoi

Our lab @MRC_LMB is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry

🌟"The thrill of asking new questions and seeing them answered... keeps the quest going." – Prof. Eva Nogales, 2023 #ShawPrize Laureate. Get ready for the 2024 ceremony!🎊 💻 Full speech: youtube.com/watch?v=PANxrH… The Nogales Lab UC Berkeley