If you want to watch the eclipse but they run out of glasses, no problem! Talk to the old cryo-EM folks around you. Let's get these babies out of the dusty corners of the lab and give them one more use...What old project did you get for your glasses? Ahmad Jomaa Aida Razi

New direction of the Lab-mRNA lipid nanoparticles, led by the excellent postdoc, Jeehae Shin. Great collaboration with Cameron Douglas and Ciaran Seath. Ciaran Seath pubs.acs.org/doi/full/10.10…

Since the outset of my career, I’ve always been fascinated by two types of dream research: (1) the intricate and dynamic biological systems, like the cellular transport machinery, and (2) the powerful imaging technologies that allow for visualization of the subtlest motions of

I am excited to share our new preprint. Human tumor suppressor protein Pdcd4 binds at the mRNA entry site in the 40S, where it blocks the eIF4F-independent role of eIF4A during recruitment and scanning. biorxiv.org/content/10.110… #CryoEM #science #mRNA #ribosome

Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs. Congrats to Anna Loveland and collab. w/Allan Jacobson! nature.com/articles/s4158…

Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! dlvr.it/T7CNnf…great collaboration with ⁦Suessmuth Lab⁩ ⁦Mankin_Vazquez_Lab⁩

We want to thank the generous funding from European Research Council (ERC) and Novo Nordisk Foundation and that allowed us to complete this work Have a look at the follow-up twetorial by @proteofrankie explaining the findings #crispr #genomeediting #CryoEM #HorizonEU

Excited to share WD Hale's work out in NatureStructMolBiol: "Allosteric competition and inhibition in AMPA receptors" Through #cryoEM, Dylan outlines how allosteric inhibition occurs, and how this process prevents positive allosteric modulation during allosteric competition. Read for

To #TeamTomo ❄️🔬: Do you also sometimes see strange filaments in your #cryoET data and don’t know what they are? 🤔 Try #FilamentID! 🪄🤓 Check out our new paper at Cell by Jannik Hugener and Jingwei Xu together with the Matos lab cell.com/cell/fulltext/… 🧵(1/5)

Our manuscript High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles is now published in Science! science.org/doi/10.1126/sc…

Excited to share our newest publication on dual RNA-seq of human neutrophils and Neisseria gonorrhoeae, out today PLOS Pathogens! A true labor of love and testament to perseverance from Aimee Potter, PhD and awesome collaborator Hervé Tettelin and team Institute for Genome Sciences University of Maryland School of Medicine

My department here at UVA continues its amazing growth with two open rank faculty positions. Come join US! apply.interfolio.com/148838

Two open rank faculty positions (preference to Assistant Professors) @ UVA Molecular Physiology and Biological Physics Department, home to cutting-edge research! Join exceptional scientists in a highly collaborative environment. Apply now using this link apply.interfolio.com/148838

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in nature rdcu.be/dRAQY collab with Deuerling Lab Shu-ou Shan Caltech Swiss National Science Foundation European Research Council (ERC) ETH Zurich

We are thrilled to share a truly exciting discovery by cryo electron tomography: the “hemifusome”- a new cellular organelle complex containing a hemifusion diaphragm! Tavakoli et al. biorxiv.org/content/10.110… Amirrasoul Tavakoli, shiqiong hu and @Becharakachar Tweetorial below (1/8)

1/8 ❄️🔬Excited to share our latest work published in Nature Communications! Led by Kaitlyn Abe and in colab with Tim Grant, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn

We find members of the TMC family of putative #mechanosensors at the tips of #intestinal #microvilli! Bechara Kachar Modeling Angela Ballesteros and molecular dynamics simulations Sotomayor Lab at OSU suggest they may be ion channels and/or lipid scramblases, like TMC1 at #stereocilia tips!

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Now on bioRxiv - Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs 🧠🔥❄️🔬 In this preprint, we reveal how glutamate gating of iGluRs is unique from PAM-activated states (!!!), and how temperature effects glutamate gating. biorxiv.org/content/10.110…

ncAAs can endow proteins with new activities, but their incorporation efficiencies during translation can be poor. Today in Nature Biotechnology, we report that altering mRNA codon usage can improve incorporation efficiency, yielding proteins with up to 3 ncAAs! nature.com/articles/s4158…