You are invited to the next webinar of the Global Frailty Network FSS Wednesday, April 10th, 2024, 12 PM ET. Dr. Emiel O. Hoogendijk from VU University Med Ctr, the Netherlands will present 'Recent Developments in Frailty Epidemiology.' Please REGISTER at mhs.webex.com/weblink/regist…

Editorial by Peter B. Bach, MD: Late-Stage Cancer End Points to Speed Cancer Screening Clinical Trials—Not So Fast ja.ma/3VL036c #AACR24

#Biomarkers of the #middle -aged brain predict #cognitive health in old age
eurekalert.org/news-releases/…

A new PCSK9i! #Lerodalcibep is a novel small recombinant fusion protein of PCSK9 binding domain (adnectin) dosed SC monthly reduced LDL by ~60%, safely, with >90% of very high risk & high risk pts achieving the stringent ESC LDL targets. #ACC24 #Lipids #LBCT

We’re so excited to watch the new PBS RadicalMedia Bloomberg Philanthropies documentary, #TheInvisibleShield about the incredible successes of public health in making modern life possible— premiering tomorrow!

The series spotlights experts, including Johns Hopkins Bloomberg School of Public Health faculty Joshua Sharfstein!

Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis…
thelancet.com/journals/ebiom…

Subcellular structure, heterogeneity, and plasticity of senescent cells
onlinelibrary.wiley.com/doi/full/10.11…

At the #CancerVaccines #AACR24 session? Check out this recent trial led by Dr. Shubham Pant Eileen M O’Reilly Elicio Therapeutics reporting results of a lymph node-targeting mutant #KRAS peptide vaccine given to patients with #PancreaticCancer and #ColorectalCancer nature.com/articles/s4159…

Presented at #ACC24 :

Hospitalized patients with acute myocardial infarction & preserved EF were assigned to receive open-label long-term beta-blocker therapy or not. Beta-blockers did not lead to a lower risk of death or MI. Full REDUCE-AMI trial results: nej.md/4akVhRx

Efficacy of #alkaline #water in conjunction w/ conventional medication for the treatment of chronic #gouty #arthritis : A randomized controlled study

⁦Atanas G. Atanasov⁩ ⁦International Natural Product Sciences Taskforce⁩ ⁦Science Communication⁩ ⁦Digital Health and Patient Safety Platform⁩ ⁦Lori Shemek, PhD⁩ Juhana Harju journals.lww.com/md-journal/ful…

This drug class is exceeding all expectations, well beyond weight loss, with new clinical trial data this week for heart disease and #Parkinsons
A rundown and where we're headed in the new Ground Truths (link in profile) and a companion podcast w/ Daniel J Drucker

Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy

molecular-cancer.biomedcentral.com/articles/10.11…

Loneliness is considered a global public health issue. The U.S. surgeon general released an advisory report in 2023 documenting an epidemic of #loneliness and a pressing need to increase social connection.
theconversation.com/loneliness-can…

Among patients with obesity-related heart failure with preserved ejection fraction & type 2 diabetes, semaglutide produced greater reductions in symptoms, physical limitations & body weight than placebo at 1 year. Full STEP-HFpEF DM trial results: nej.md/3TPKpUC

#ACC24

Discontinuing renin–angiotensin system inhibitors before non-cardiac surgery did not reduce myocardial injury. Read the SPACE trial paper.
doi.org/10.1093/eurhea…
#surgery #hypertension #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

The 'middle-aging' brain: Trends in Neurosciences cell.com/trends/neurosc…

In randomized clinical trials of cancer screening, incidence of late-stage cancer may be a suitable alternative end point to cancer-specific mortality for some cancer types but is not suitable for others, finds meta-analysis of 41 RCTs. ja.ma/3Uf3jG9 #AACR24

A diabetes drug related to the latest generation of obesity drugs can slow the development of the symptoms of Parkinson’s disease go.nature.com/3U72YF2

#Zinc deficiency induces #hypertension by paradoxically amplifying #salt sensitivity under high salt intake in mice

⁦Atanas G. Atanasov⁩ ⁦International Natural Product Sciences Taskforce⁩ ⁦Science Communication⁩ ⁦Digital Health and Patient Safety Platform⁩ ⁦James DiNicolantonio⁩ ⁦Chris Masterjohn⁩ ⁦P. D. Mangan Health & Freedom Maximalist 🇺🇸 link.springer.com/article/10.100…

Buck Scientists Identify How Dietary Restriction Slows Brain Aging & Increases Lifespan

Kenneth Wilson, Pankaj kapahi & Lisa Ellerby Buck Institute

buckinstitute.org/news/buck-scie…