Me: Ever had thoughts that life is not worth living anymore and that you'd want to end it?

Patient: I worked too hard to be alive to have such thoughts.

Working with patients with cancer sure puts things in perspective

The lights are moving. If you move your fingers over the arrows, you'll still perceive movement.

I made it

Andrew Kiselica, PhD, ABPP Vincent Planche Madhav Thambisetty Simon Mead Suzanne E Schindler Ryan Townley Seb Walsh Ash Paul Eric Widera, MD Andrew Lees Robert Howard Jason Cohen cachuchas Lon S. Schneider, MD Michael Schöll Stefano L. Sensi Alberto J Espay Nicolas Villain Kasper Planeta Kepp Timothy Daly, PhD Gill Livingston Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD FORTUNE TIME Erin Prater TIME Financial Times Hannah Kuchler CTAD NIH Alzheimer's Association Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Maastricht University Kariem Ezzat Dr Ben Underwood NHS England The Observer This plot captures normal aging and the full spectrum of neurodegenerative conditions. The A+ orange dots are amyloid-PET positive and they occur everywhere across this spectrum.

Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease #neuropath
jamanetwork.com/journals/jaman…

Great meta-analysis showing biomarker odds ratio conversion rates from cognitively normal to MCI or dementia.

A-,T+ OR ≠ sig
A+,T- OR 2.04
A+,T+ OR 13.46

Older age A+ decreases odds ratio of conversion.
alzres.biomedcentral.com/articles/10.11…

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* Big euroimaging and multi-omic data?
* Neurodegenerativ disease?

The BioFINDER is looking for a talented postdoc to sink their teeth into some rare and exciting data!

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lu.varbi.com/en/what:job/jo…

In relation to this study, my paper in Brain (1999) predates the JAMA reference of 2021, and which proposed for the first time the critical rôle of the ventromedial prefrontal cortex in decision-making abnormalities in bvFTD, ref: academic.oup.com/brain/article/…. Nick Corriveau-Lecavalier, PhD Ash Paul

Group-wise comparisons of FDG-PET hypometabolism: Pair-wise comparisons between each patient group and cognitively unimpaired controls matched for sample size, age and sex.

Great work by Nick Corriveau-Lecavalier, PhD

Timothy Daly, PhD Madhav Thambisetty Eric Widera, MD Simon Mead Andrew Lees Robert Howard Jason Cohen radical optimism Lon S. Schneider, MD Seb Walsh Michael Schöll Vincent Planche Stefano L. Sensi Alberto J Espay Nicolas Villain Kasper Planeta Kepp Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD FORTUNE TIME Erin Prater TIME Financial Times Hannah Kuchler CTAD NIH Alzheimer's Association Howard Gleckman American Geriatrics Society Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin U.S. FDA NICE Raymond Koopmans Maastricht University Kariem Ezzat Dr Ben Underwood NHS England The Observer Xiong-feii Ekaterina Zotcheva Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases academic.oup.com/brain/article/… via Nick Corriveau-Lecavalier, PhD et al

It's me!

Corriveau-Lecavalier et al. show that dementia syndromes targeting executive functions have different signatures of brain degeneration to those affecting personality and behaviour, with implications for diagnosis and symptom management. tinyurl.com/5n8prmbx

Probably too late to ask but what do we mean by 'emergeant property' from a neurscience perspective?

Took a decently long break from Twitter but the truth is that, even if this platform is nowhere near what it used to be, I missed the connections and learning opportunities. Screw Elon nonetheless

***Hot off the JAMA Neurology e-press***
While seeking to investigate clinicopathologic heterogeneity and glial activation patterns of #Alzheimers ...we created a corticolimbic index (CLix) to better capture the individuality of tangle distribution.

jamanetwork.com/journals/jaman…

🚨Paper Alert🚨
Excited to share our new piece with Robin Michalon from EHESS Centre Alexandre-Koyré
While debates rage on following Alzheimer's Association new #Alzheimer ’s criteria we propose (Open Access) a historical perspective on what Alzheimer’s is.
A thread👇🏻
1/21
onlinelibrary.wiley.com/doi/10.1111/en…

Grateful to Naomi Kouri, PhD, Isabelle Frankenhauser, Kelsey Caetano-Anolles, Murray lab, and collaborators for fantastic effort!

It definitely took a village to get this study off the ground. Great to get to work with Sydney Labuzan 👩‍🔬🧠 Baayla DC Boon Dr. Christina Moloney Jessica Tranovich…

I am not crying you are

Data driven 'Jack curves': We used an amyloid PET clock to determine the timing of biomarker change in sporadic Alzheimer disease in terms of years until symptom onset.
#ENDALZ Washington University Department of Neurology
onlinelibrary.wiley.com/doi/10.1002/an…