Uncover the influence of environmental toxicants on brain disorders at the Brain and Environment Symposium on May 20, 2024 - Washington, DC. Learn more: brainandenvironment.org #GreenerBrains Brain & Environment Symposium

Do you know the story behind Henri Gob, Astasia Abasia and the 'Swivel Chair Test' for Functional Gait Disorders? New letter Movement Disorders Clinical Practice follows great article by Lagrand/Lehn and colleagues which also examined Whack a Mole sign.
Key Points:
- A seminal paper in the diagnosis of

Should we be more actively working to address levodopa phobia? Long term followup of Levodopa in EArly Parkinson's disease study was just published and it should enlighten our 'shared decision making' especially when we meet people wishing to avoid levodopa. There was no

We appreciate Dave Iverson, an esteemed writer, filmmaker and our Robert B. Stockdale Lecture Fund guest speaker, for his generous donation to our institute. Dave donated proceeds from his book signing and author talk during this year's Parkinson Symposium. Thank you, Dave!

Results are in from a fecal microbiota transplantation study in Parkinson's (GUT-PARFECT): a small double-blind, placebo-controlled, randomized, phase 2 trial from Bruggeman and colleagues just published in The Lancet eClinical Medicine Discovery Science.
Key Points:
- The

Kara Johnson kicked off the week w/ a presentation on her work using evoked resonant neural activity (ERNA) which is a high-frequency (∼200–500 Hz) stimulation evoked response has been proposed as a candidate neural signal in deep brain stimulation (DBS) for Parkinson's disease.

There's no such thing as a self-made man or woman. No one succeeds without support.

'I did it on my own' is a sign of insecurity and entitlement. Acknowledging help is a mark of confidence and humility.

Giving credit to others doesn't undermine you. It elevates them.

Are GLP-1 agonists 'fire prevention for the brain?' In 2018 Lena Brundin, Liza Bergkvist & Patrik Brundin MD PhD published this in News and Views in Nature Medicine and it may be time for us to re-read their thoughts in the wakeof the NEJM on lixisenatide for Parkinson's. The power of

Have you ever looked at disease classification over time? The nosology can be informative. In my mind it demonstrates how we must be flexible as we learn new aspects of any disease. Below is a fascinating article on Alzheimer's, and I would argue as folks debate classification of

Case Records of the Massachusetts General Hospital: A 58-Year-Old Woman with Confusion, Aphasia, and Abnormal Head Imaging nej.md/49DGwrP

Saturday quiz: Who said, 'I have seen it. It is wrong. What are you going to do about it?' It was of course Nelson Mandela, who spent 27 years in prison and would later lead South Africa in a peaceful transition to democracy and to the improvement of human rights for all. One of

🧠 Curious about how neurons are wired in the human cortex?

Our Science Magazine study tested over 7,000 connections and revealed key differences from rodents:
'Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit'. 🧵👇science.org/doi/10.1126/sc…

Great meta-analysis showing biomarker odds ratio conversion rates from cognitively normal to MCI or dementia.

A-,T+ OR ≠ sig
A+,T- OR 2.04
A+,T+ OR 13.46

Older age A+ decreases odds ratio of conversion.
alzres.biomedcentral.com/articles/10.11…

Does lesion location or lead location impact your outcome from focused ultrasound or DBS? You bet it does. Lot's of papers on this for DBS and classical thalamotomy, and now one for FUS by Arcadi, Rodríguez-Oroz and colleagues in Movement Disorders Journal.
Key Points:
- 127 people

How do GLP-1 agonists like exenatide, lixisenatide and others work to potentially combat neurodegenerative diseases like Parkinson's? We don't know, however I like this picture and I think it is worth investing some deep thought into the possibilities. We are interested in your

Use FGATIR, EDGE, LAMA, or other T1 inv images? Wish you could get them all in 1 scan? Introducing ingenious work by Vishal Patel streamlining our synthetic T1 inversion work into real-time viz tool! See new publication below & link to download in 🧵

link.springer.com/article/10.100…

Preprint 🚨 This one is important for invasive #Parkinson #neurotech of the future. Deep brain stimulation suppresses oscillatory hyperdirect pathway communication. So does dopamine! Check our #Parkinson study spearheaded by Einstein Center for Neurosciences Berlin #PhD Thomas S. Binns 🧵
biorxiv.org/content/10.110…

Localization with Lead-DBS revealed spatial peaks of local power in motor cortex. At the level of STN, beta power peaked within 0.5 mm of the previously described DBS sweet spot. See 16 contact high-density STN recording in panel C.