Check out our lab’s latest Review on transposable elements (TEs) Trends in Genetics. We focus on vertebrate TEs, discussing both their epigenetic silencing and domestication. Put together by Miguel V. Almeida, @gregverne, Audrey Putman, PhD & Eric Miska cell.com/trends/genetic… A short 🧵:

Nature research paper: Epigenetic regulation during cancer transitions across 11 tumour types go.nature.com/3SjCrUL

Don't miss Zunpeng Liu 's #ASHG talk on #SingleCell #MultiRegion #Epigenomic dissection of #Alzheimers next in Room 207A/Level 2 (11:30am) #ASHG23 Integrate: 576 samples, 2.3M cells (1.5M #scRNA x 900k #scATAC), 6 brain regions, 30 cell types and subtypes Results: 419k regulatory

Really fortunate to work with the amazing and lovely team! 😊 ❤️ Thank you so much Kellis lab family! 🙏 🫶

Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation nature.com/articles/s4146… #journals #feedly

Repetitive DNA sequence detection and its role in the human genome | Communications Biology nature.com/articles/s4200…

A new H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young ERVs｜ nature.com/articles/s4158…

A new paper from JaffreyLab reveals that phospholipids can partition into protein condensates depending on the length of their acyl moiety and influence the properties of the condensates. Free to read link at rdcu.be/drmNe

Really honored to speak at the @EMBL symposium, alongside many of my friends and colleagues! :-) phdsymposium.embl-community.io/main/

An intronic LINE-1 regulates IFNAR1 expression in human immune cells dlvr.it/SzYDHG

“The Information Theory of Aging” was published today. Free copy Nature Aging rdcu.be/dtGSC

We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by Daniel Kirschenbaum, Ken Xie, Florian Ingelfinger, Assaf Weiner sciencedirect.com/science/articl…. (1/19)

Fantastic to have our paper "Deciphering cell states and genealogies of human hematopoiesis" published today in nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by Chen Weng in a wonderful collaboration with Jonathan Weissman's Lab! nature.com/articles/s4158…

Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions. Although ALS affects #movement vs. FTLD #cognition, the two are nearly identical in the cell types, genes, and

Excited to share our #MultiRegion #SingleCell dissection of #Alzheimers out in nature today studying #Reelin in #RegionSpecific #NeuronalVulnerability, #CholineMetabolism and #PolyAmineBiosynthesis in #CognitiveResilience, #Astrocyte diversity, #Thalamus-specific #Interneurons,

To the colleagues and friends who find our paper overwhelming, and instead prefer to write and read more manageable papers with more focused messages: I respect your perspective and your approach to science greatly, and find it invaluable, of course. Both broad and focused

How can a paper have “too much data”? The only problem is people have too little time

I am excited to see our paper AJHG. We introduce ‘hypometric genetics,’ an approach to investigate the genetic basis of binarized traits representing the presence of below-the-limit-of-quantification quality control indicators. Paper📜: authors.elsevier.com/a/1jzoqgeXA9Lf Thread: 🧵

Amazing new GWAS resource for CSF and brain metabolite levels (Metabolon, Inc.)🧠🧬 👉2,602 CSF samples of 440 metabolites 👉1,016 brain samples of 962 metabolites 📜Paper: nature.com/articles/s4158… 📊Summ stats: ebi.ac.uk/gwas/ [accession numbers GCST90317902–GCST90319303]

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… Jason Buenrostro Fei Chen Lab Ajay Labade Caroline Comenho zack chiang Science Magazine