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A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and ... biorxiv.org/cgi/content/sh… #biorxiv_genomic

Really excited to have my first preprints out!! Huge thanks to the exceptional mentor Junyue, all lab members, and support from Rockefeller University !!!!

Interested in massive-scale combinatorial indexing technologies? Check out our next Center for Integrated Cellular Analysis virtual series. Two students from Junyue's lab will introduce EasySci-RNA (1M cells for $700!) to study aging and neurodegeneration Free registration: nygenome.zoom.us/meeting/regist…

Excited to share our latest preprint from Cao Lab - PerturbSci-Kinetics, led by brilliant Zihan Xu! The technique captures single-cell transcriptome, nascent RNA, and sgRNA identity in pooled CRISPR screens, for identifying key regulators of RNA kinetics. tinyurl.com/2nyuz49a

I am thrilled to share our latest research, PerturbSci-Kinetics, a novel low-cost and scalable combinatorial-indexing single-cell technique enabling the co-capture of transcriptomes, nascent transcriptomes, and genetic perturbations. (1/5)

Congrats Zihan Xu This is brilliant!!

Retrospective analysis of enhancer activity and transcriptome history go.nature.com/3lZYa66

Our next Center for Integrated Cellular Analysis virtual seminar will be on 4/4 at 12PM ET Zihan Xu will present 'PerturbSci-Kinetics' a novel combinatorial indexing method to capture single-cell transcriptome, nascent RNA, and sgRNA identity in pooled CRISPR screens. Free registration: nygenome.zoom.us/meeting/regist…

Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens go.nature.com/3RBpW6I

PerturbSci-Kinetics for high-throughput functional characterization of RNA dynamic regulators is published today Nature Biotechnology, led by fantastic Zihan Xu from our lab Rockefeller University!

How does aging impact the proliferation and differentiation rates across diverse cell types in the brain? Explore this question with TrackerSci in Cell: shorturl.at/kzCDJ. Kudos to the incredible Ziyu Lu and Melissa Zhang of our lab Rockefeller University!

In the latest issue! Tracking cell-type-specific temporal dynamics in human and mouse brains dlvr.it/SwsGSq

Single-cell characterization of many genetic mutants at the scale of the entire organism! A great collaboration with Malte Spielmann lab and my fantastic colleagues in Jay Shendure lab!

EasySci is now published! 🌟 A big congratulations to Andras, Ziyu Lu, and Jasper from our team at Rockefeller University. Planning to prepare a scRNA-seq library for 1 million cells on a budget of just $700?Discover our detailed protocol here: nature.com/articles/s4158…

Wei Zhou (Wei Zhou) is a staff scientist in Junyue's lab. She studies how a cell population maintains homeostasis, and how it is disrupted in aging and aging-related diseases, through profiling + perturbing cell dynamics at single-cell resolution. #AANHPIHeritageMonth

Thrilled to introduce IRISeq, a scalable, cost-effective and imaging-free spatial genomic technique for mapping mammalian brain aging, developed by incredible Abdul AbdulAbdul and Weirong from our lab at Rockefeller University! biorxiv.org/content/10.110…

I'm thrilled to share our new #bioRxiv preprint from ⁦Junyue⁩ lab at ⁦Rockefeller University⁩! We present PerturbFate, a high-throughput single-cell CRISPR platform profiling nascent/pre-existing RNA, steady-state RNA & chromatin accessibility. biorxiv.org/content/10.110…

Thrilled to share our latest preprint led by the fantastic student Ziyu Ziyu Lu! We constructed a scATAC-seq atlas profiling > 500 mouse tissues to explore cell population dynamics during mammalian aging and the associated chromatin landscape changes: biorxiv.org/content/10.110…