🚨🚨Please RT!!📢📢 Still time to register and submit Poster abstract for bit.ly/EdinPBS2024 ! Higgs Centre for Theoretical Physics Physics Astro @ Edin 💵💷💶We offer Travel Fellowships ! 🚨📢

Super excited about our latest preprint where we show that HIV integrase (IN) can compact the viral DNA genome. Great collaboration with Willem Vanderlinden, Steven De Feyter, zeger debyser, and Laura Filion. A summary 🧵 (1/n) doi.org/10.1101/2024.0…

Obituary: Roeland Nolte 1944-2024. I wrote this with Bert Meijer about our dear friend. Quoting Hávamál (Viking text): I know one thing which never dies: the reputation of each man. Roeland´s good reputation will certainly live forever. Nature Nanotechnology see: rdcu.be/dDcT0

Want to model protein-mediated DNA compaction/condensation at a coarse-grained level and classify the resulting complexes? Check out our latest preprint with Laura Filion's lab @UniUtrechy and Willem Vanderlinden The University of Edinburgh! A summary (1/n) biorxiv.org/content/10.110…

We are excited to announce our new manuscript is on bioRxiv edin.ac/3z7hhBH. We use super-resolution imaging, molecular biology and polymer simulations to show that nuclear RNA forms an interconnected network of microgels. Well done everyone!

Our paper on how post-translational modifications modulate nucleosome-nucleosome interactions and conformational landscapes is out in Journal of Molecular Biology! doi.org/10.1016/j.jmb.… Congratulations Yi-Yun et al! Work at Universität München Center for NanoScience LMU Utrecht University Faculty of Science, Utrecht University The University of Edinburgh .

Check out our work on modelling protein-mediated DNA compaction/condensation at a coarse-grained level and on classifying the resulting complexes, just out in Biophysical Journal doi.org/10.1016/j.bpj.… Universität München Center for NanoScience LMU Utrecht University The University of Edinburgh

Excited about the to-the-point and insightful perspective on our coarse-grained DNA-protein modelling and classification work by Petr Šulc in Biophysical Journal doi.org/10.1016/j.bpj.…

Super excited to share our latest work looking at mechanisms that contribute to local hexatic and nematic ordering in tissue monolayers! Intercellular friction and motility drive orientational order in cell monolayers | PNAS pnas.org/doi/10.1073/pn…

📢New paper alert!! With Wyoming Water Bear Lab Alex Holehouse Stephen Fried JHU we take a look at how an entire proteome survives desiccation. TLDR: Desiccation tolerance is encoded in specific residues on the protein surface, and occurs primarily in biosynthetic enzymes. shorturl.at/U5VS1

A great line-up of speakers at next week's 24th meeting of the Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network

Come visit us in Edinburgh for this great conference.

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: science.org/doi/10.1126/sc…

🚨🚨Please RT! 📢📢 Still time to submit short talk abstract for EdinPBS2025! Five themes this year: · Mechanobiology · Protein pattern formation · 4D Genome · Stochastic biology · Biohydrodynamics bit.ly/EdinPBS2025

My lab has postdoc openings in the following areas: 1) Structural biology and single molecule biophysics; 2) Developing novel genome editing methods; and 3) Protein and RNA engineering. Please share the info with your trainees, and RT please. 🙏 postdocs.yale.edu/yale-postdocto…

Excited to share our latest preprint biorxiv.org/content/10.110… Alba Abad Anji Naduvath Biological Sciences | University of Edinburgh Gene Center Munich

How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell

1/4 📢🥳now online: BROWNIAN DNA COMPUTING - Unlike fuel-driven molecular computing with high-energy barriers, it exploits thermal fluctuations. Inputs rectify state access, enabling fast, low-energy computation. 📜More in our preprint: biorxiv.org/content/10.110…

It has taken a lot of work and a long journey, at the end we show that there is a colloidal way amino acids stabilize proteins. A great collaboration with Alfredo Alexander-Katz that proposes new theory on colloidal stability. Just published in nature rdcu.be/eFrqm

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I3vVUPVb…