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A historic milestone for neuroscience! It's been a fantastic journey for the #FlyWire Consortium. This special edition of Nature showcases the power of open science, with nine papers that not only describe the fly connectome, but also make discoveries using it.

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

Today's The Nobel Prize for John Hopfield recognizes only one of his contributions - he's a true polymath. I strongly recommend his solo author PNAS papers (i) long-range e- tunneling in proteins (1974), (ii) kinetic proof-reading (1974), (iii) Hopfield nets (1982). Each is a gem!

Clearly, we’re now in the golden age of biology: physiology/medicine Nobel to tiny RNAs; physics Nobel to neural networks; chemistry Nobel to protein structure prediction.

"Quantifying constraint in the human mitochondrial genome" nature.com/articles/s4158…

It is approaching 20 years since the passing of Stan Korsmeyer. Stan was one of the best scientists, best mentors and best people I have known in my life. I miss Stan very, very badly.

Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed and available at PNASNews! pnas.org/doi/10.1073/pn… By M. Foged Department of Immunobiology at UNIL Faculté de biologie et de médecine (inactif) Christian Münch Vamsi Mootha #N6AMT1 #mtDNA #RNA_processing A recap 🧵

Excited to share our new paper led by Matt Kukurugya in collaboration with Saharon Rosset showing that the Warburg Effect is the result of faster ATP production by glycolysis than respiration. A 🧵... 1/n pnas.org/doi/10.1073/pn…

Thrilled to share our approach for language model-guided discovery of unknown mammalian metabolites: DeepMet. We’ve now used this approach to discover ~50 new human and mouse metabolites! biorxiv.org/content/10.110…

Hypoxia in a pill! Chronic, continuous 11% FIO2 suppresses brain pathology in models of mitochondrial disease and aging, but we need practical alternatives. We combine a Hb "left-shifter" with a HIF2a inhibitor to achieve therapeutic hypoxia in mice. jci.org/articles/view/…

Tabla legend #ZakirHussain just succumbed to idiopathic pulmonary fibrosis (IPF). RIP. I know so many Indian Americans, all in their 70s-80s, with IPF or related ILD. Has anyone else noticed this pattern? If so, what might be the mechanism? Genes? Pollution? Bird feathers?

Excited to share our new paper in Cell on Digital Phenotyping from Wearable Biosensors using AI to characterize Psychiatric Disorders & identify Genetic Associations (led by Jason Liu & Beatrice Borsari) doi.org/10.1016/j.cell…

Let’s not forget metabolism!

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above

Wow very big news for biomedical research

As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD Rahul Gupta w/ NealeLab /labneale.bsky.social. shorturl.at/IqYY8

Very cool work by Rahul Gupta NealeLab /labneale.bsky.social Vamsi Mootha, and delighted to contribute. Super cool new connections between mtDNA mutational burden in blood & clonal hematopoiesis 👇

Using population and statistical genetics across 750,000 people, we have identified a putative mechanism for an important aging biomarker: the apparent age-related mtDNA mutation accrual in blood. Very excited this is up!

Mitochondrial health is poised to become a pillar of the MAHA movement, Hannah Seo 서한나 reports. theatlantic.com/health/archive…

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.