Very happy to join the Max Planck Institute MPI for Biology of Ageing as a Research Group Leader in July 2024! Reach out if you are interested in joining our growing team #metabolism #energyhomeostasis #exercise #ageing

age.mpg.de/sprenger

New review to read:
DOI: 10.1146/annurev-biochem-052621-092014

mtDNA heteroplasmy dynamics are so complex, even paradoxical. To understand why, we combined precise mtDNA editing w/a new method SCI-LITE. In dividing cells, selection (not drift) acts on cell (not intracellular) fitness to shape population heteroplasmy. rdcu.be/dFDCY

New issue! We mark #EarthDay (4/22) with an article by Hannah Pallubinsky (and a beautiful cover art from Alisa Singer) discussing the effects of heat on human health.
Plus articles on nucleoside metabolism, liver disease, breast cancer and more!
cell.com/issue/S1043-27…

March milestones:
✅ Finished my 1st year of PhD.
⭐️ I had the honour to give a short talk about new approaches to identifying new #mitochondrialdisease genes during the #MitoMed24 conference at Hinxton Hall Conference Centre, Cambridge (UK).
#MitochondrialResearch #PhDVoice

Continuing our study of the somatic segregation of pathogenic mitochondrial DNA variants. T cell activation selects against the m.3243A>G variant in a manner that persists with time/age. Vamsi Mootha Broad Institute MGH Neurology Dept. of Molecular Biology, MGH
pubmed.ncbi.nlm.nih.gov/38499449/

Register now for the upcoming EMBO Workshop on mitochondrial gene expression 19-23 May 2024 - registration closes on Mar 24!

meetings.embo.org/event/24-mitoc…

Online Now: Nucleosides are overlooked fuels in central carbon metabolism dlvr.it/T3WJG6 #trends #endocrinology #metabolism

Delighted to introduce PMF-seq: a new way to link genetic perturbations to detailed bioenergetic phenotypes. We use the method to dissect genetics of mitochondrial ETC branching and acute tBID action. Led by T.L.To ⁦Broad Institute⁩. nature.com/articles/s4225…

New interview at the Faculty of Biology & Medicine Faculté de biologie et de médecine (inactif) (in French)

news.unil.ch/display/170833…

Come join us in Poland! Beautiful line up of speakers with lots of #new_PI (but not only!).

#EMBOmitochondrialGene

meetings.embo.org/event/24-mitoc…

Join us 19th-23rd of May 2024 for an exciting #EMBO Workshop in Jozefów, Poland:

𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐁𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐌𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐆𝐞𝐧𝐞 𝐌𝐚𝐢𝐧𝐭𝐞𝐧𝐚𝐧𝐜𝐞 𝐚𝐧𝐝 𝐄𝐱𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧

Registration open now!

meetings.embo.org/event/24-mitoc…

Join us on 𝟏𝟗-𝟐𝟑 𝐌𝐚𝐲 𝟐𝟎𝟐𝟒 in Poland for the #EMBO Workshop! The website of the workshop and registration are 𝐎𝐏𝐄𝐍. meetings.embo.org/event/24-mitoc…. Need more information, contact us at: 𝐦𝐢𝐭𝐨𝐠𝐞𝐧𝐞𝟐𝟎𝟐𝟒@𝐢𝐛𝐛.𝐰𝐚𝐰.𝐩𝐥
EMBO

Our lab is looking for 143B 'rho0' cells (no mtDNA) 👀.

Would anyone agree to send us some?

Very happy to see this out, congratulations to first author Josh Meisel and all co-authors! 👏🏻

Delighted to share new study by Tslil Ast now Weizmann Institute w/ Y. Itoh, D. Suess, Alexey Amunts showing (1) the Fe-S proteome is destabilized w/frataxin loss, (2) mitoribosome assembly factor METTL17 harbors a 4Fe-4S cluster, serving as an Fe-S checkpoint for mito translation.