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Woohoo! Grateful to Genome Organisation Australia for the honor of being named the Young TAD 2023! 🧬 I love that we have a fun and supportive network of genome organization aficionados!

“Fall in love with the problem, not the technology”

Proximity to nuclear speckles–areas dense in mRNA splicing regulators–determines mRNA splicing efficiency. Variation in distance between genes and nuclear speckles drives cell-type specific differences in splicing. Prashant Bhat Mitch Guttman ow.ly/cszr50RHV4h

Now Online Splicing regulation through biomolecular condensates and membraneless organelles dlvr.it/T7Bmcw

Thanks @philipcball for showcasing our work!

It was fun to present at my first The RNA Society meeting in Edinburgh! Thanks to the organizers for a great meeting and the audience for the engaging questions! #RNA24 Want to chat about speckles and splicing in different cellular contexts, including disease processes? DM me!

I’ve had the chance to interact with all of these amazingly bright and kind humans - congrats to all on their amazing PhDs from Lior Pachter lab! Go Caltech!

Cheer on UCSF Department of Emergency Medicine’s Kishan Patel, MD, as he competes on CBS #Survivor47 in the Fiji islands! This ER doctor thrives in high-pressure situations. Tune in to see how he outwits and outlasts the competition. #UCSFProud UCSF Health tiny.ucsf.edu/CvJpUD

We are really excited to share this story! We discovered that a major function of the KSHV RNA, kaposin, is as an architectural non-coding RNA that recruits nuclear speckles proximal to viral genomic RNA. biorxiv.org/content/10.110…

How do you turn a condensate inside-out? Congrats to Sofi Quinodoz & Lifei jiang & co-authors on amazing study from our lab & Denis LJ Lafontaine + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) biorxiv.org/content/10.110…

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

Elegant study by Emma Kowal & Burge Lab identifying 5'UTR intron sequences that enhance mRNA expression. Cool to see the integ. reporter + higher Dox leading to greater intron-med. enhancement. Suggests a feedback loop between transcription & splicing to boost gene expression!

Delighted to read this article by The Scientist featuring our work on nuclear speckles! Also features quotes from Mitch Guttman and Andrew Belmont. the-scientist.com/gene-proximity…

I am excited to share our review, published online today Nature Reviews Molecular Cell Biology. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…

Hi! I’ll be speaking at Harvard Medical School Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…