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Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners academic.oup.com/bib/article/25…

Happy to share that Humatch, Oxford Protein Informatics Group (OPIG) new humanisation tool, is now available at mAbs - doi.org/10.1080/194208… Please also check out the code on GitHub (web server coming soon!) - github.com/oxpig/Humatch Highlights🧵in previous tweet - x.com/LewisChinery/s…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Excited to share our latest pre-print! 🌟 Collaboration between Institute for Protein Design & NIH tackles the global threat of #influenza & the need for #H5N1 countermeasures. #CryoEM reveals how conserved motifs & water molecules help achieve broad protection. biorxiv.org/content/10.110…

First work led by our lab is now published in Nature Communications nature.com/articles/s4146… A big thanks to everyone involved in making this happen!

1/ We are excited to share our new paper from Fahd Al Qureshah, PhD | فهد آل قريشه published today in Journal of Experimental Medicine about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem.20…).

1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology

Our new work on optimising CAR-T cell sensitivity is now on bioRxiv! Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes biorxiv.org/cgi/content/sh…

Excited to share our paper in Nature Immunology Congrats to Xin (Co-first) and all the other authors (Vamsee_Mallajosyula, Karan Kathuria and more). Special thanks to Prof Mark Davis for all his mentorship and guidance! UCPH Healthscience Stanford Medicine Lundbeckfonden nature.com/articles/s4159…

1. Tertiary Lymphoid Structures (TLSs) – on demand lymphoid aggregates that assemble in inflamed tissues/cancer to regulate immunity   But how? What molecule triggers? What cells induce?   TODAY in nature nature.com/articles/s4158…   Long-term #PDAC survivor PART4 – TLSs   🧵1/25

I am over the moon to finally share my Ph.D. research with the world!🤩🤩🤩 We used a new Il21r-flox mouse model to decipher the B-cell-intrinsic role of IL-21 signaling. cell.com/cell-reports/f…

I am happy to share our new preprint on Enterovirus-D68 and its glycan receptor specificity! #Enterovirus #Glycotime biorxiv.org/content/10.110…

Single-molecule live-cell RNA imaging with CRISPR–Csm go.nature.com/3EJPKsM

Out Now! Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype bit.ly/3ZozbKC #Influenza #Antibodies #Immunology

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein

Antigen-specific antibodies secreted by plasma cells are rapidly identified using microfluidics and fluorescence-activated cell sorting (FACS) go.nature.com/4dHLaHB rdcu.be/etg8W

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

Out Now! Molecular organization of the New World arenavirus spike glycoprotein complex bit.ly/45vyD7L #Arenavirus #MolecularBiology #CryoEM

Excited to share our new Nature Microbiology paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩Colin Mann Harvard Micro The PhD Program in Virology at HMS nature.com/articles/s4156…

Nature research paper: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function go.nature.com/4mnPdO3