Podcast🎙️: Frontier of Immunological Engineering w/ Darrell Irvine

🚀Explore Darrell Irvine's journey from physics to #Immunology and future predictions for 2050. Discover vaccine & T-cell innovations!

Shoutout: Alloy Therapeutics, Inc., Ankyra Therapeutics & more

buff.ly/3HoLVHH

Check out Luciano’s exciting work on cytokine CD45 targeting!! 👇🏼

Prof Darrell J. Irvine was elected to the National Academy of Medicine for 2023 “for the development of novel methods for delivery of immunotherapies and vaccines for cancer and infectious diseases.” news.mit.edu/2023/researche… National Academy of Medicine

So pleased to report that our Mount Sinai-Yale long COVID (MY-LC) paper with @putrinolab & others is now published!! Proud of the hard work of all who contributed. We found biological signatures that can distinguish people with vs. without #longCOVID (1/) nature.com/articles/s4158…

The Stark Lab MIT Dept of BE and Koch Institute at MIT opens January 2024! We are recruiting curious and motivated scientists at all levels.
Learn more about our work and how to join our team: jstarklab.com 🧬
Please share widely! #immunoengineering #synbio #glycotime #newPI

1) In 1979, Tew and Mandel published a visionary answer to a longstanding question:

How long is antigen retained in the draining lymph node after immunization?

🧵

Short answer: quite a while
bit.ly/TewMandel1979

Another great collaboration with Mark Saltzman’s lab. We showed that polymer nanoparticles poly(amine-co-ester) PACE can be used to deliver mRNA as a 👃🏼 #mucosal nasal vaccine to protect mice from lethal SARS-CoV-2 challenge. Tianyang Mao Benjamin Israelow

science.org/doi/10.1126/sc…

Extremely happy to announce that the website for the Zegarra-Ruiz Lab UVA-MIC UVAimmunology is live! Check out our research goals, lab members, and more here: immunology.virginia.edu/Zegarra-Ruiz/
#PeruanosEnElExtranjero #newlab #newPI

It was great collaboration with Iannis Aifantis #nyu #nyu langone. This is also the first article on I/O from my young lab. Many thanks to michele pagano, Peter Cresswell Yale Department of Immunobiology, Patricia Dahia and Eureka Therapeutics! Congratulations to talented postdoc xufeng chen Qiao Lu !!

We are recruiting Postdoctoral Fellows with expertise and interests in polymer chemistry, protein engineering, and/or nucleic acid delivery to lead several new #immunoengineering projects! Come join our Wilson Lab UNL team by applying at: lnkd.in/gmGG542Q.

Looking forward to giving this talk next week. Thanks Xu Zhou (周旭) PhilipAhern and the organizers for the invitation!

Does the innate immune system recognize metastatic cells and control their growth?

Orr-El Weizman et al found that type 2 dendritic cells and natural killer cells orchestrate very early immunity against metastatic cancer cells in the lung 👇🏽 (1/)

journals.aai.org/jimmunol/artic…

The COVID-19 pandemic is now more challenging due to the Omicron variants. Robust public health measures, research and global cooperation are critical in addressing this crisis. Our recent Science Translational Medicine study is particularly important for countries relying on CoronaVac vaccines👇👇

This week's special issue on #CellEngineering in Science Magazine includes:

• a review on future of #engineered #immunotherapies by Darrell Irvine, Dr Marcela Maus, David Mooney, & Wilson Wong:

bit.ly/Sci_abq6990

Hello! I am hiring postdoc(s) interested in understanding how to maximize breast milk protection against viral diseases & better define mammary gland/milk immunology. Job posting here: langelresearchteam.com/join-us. Email ([email protected]) or DM me with questions. Pls RT!

Prime 💉 & Spike: 👃 @TianyangMao and Dr. Benjamin Israelow showed that primary vaccination followed by an #intranasal spike vaccine induces mucosal immunity against sarbecoviruses.

Prof. Akiko Iwasaki

Science Magazine paper: bit.ly/3UGkE7Z
Discussion: bit.ly/3fSf8Az

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity: Cell Reports cell.com/cell-reports/f…

Congratulations to the members of Yale Center for Infection and Immunity Tianyang Mao Benjamin Israelow Prof. Akiko Iwasaki et al for the new publication on Prime and Spike👃🏽 nasal booster strategy!
New vaccine approach can help jumpstart immune response to COVID-19 app2.cision.com/redir?s=142508… via trendkite

Science Magazine First Release this week: Tianyang Mao, Benjamin Israelow, Prof. Akiko Iwasaki & al
report protective #mucosal immunity in animal models of #COVID19 using a nasal booster w/ recombinant spike protein or spike mRNA—a method called 'Prime & Spike'!

bit.ly/Sci_abo2523

Just published Science Magazine
A nasal vaccine booster (after primary vaccination) induces mucosal immunity —IgA, memory B and T cell—against the sarbecovirus family in the experimental model
science.org/doi/10.1126/sc…
by Prof. Akiko Iwasaki Tianyang Mao and team Yale Department of Immunobiology Yale School of Medicine