Ben Horowitz on the importance of culture: "A culture is not a set of ideas, it’s a set of actions." "If you define your culture as a kind of set of ideas—integrity, do the right thing, we have each other’s backs, or any of these ‘corporate values’—it’s actually just a bunch of

"You can teach a physicist finance but you cannot teach a finance person physics." - Jim Simons

google quietly dropped a monster called Aletheia. it’s a math specialized version of gemini with perfect IMO score. destroys every other LLMs in the benchmark. model is not publicly available yet but designed to crack real scientific problems.

"Good Theory Should Prune Rather Than Grow The Knowledge Tree." I was watching a YouTube lecture by David Tse (Stanford), and he quoted his advisor Bob Gallager with a line I can’t shake: Good theory should prune rather than grow the knowledge tree. Most of us start out

📁 Dario Amodei, CEO of Anthropic, says the real AI moats will not be in apps, but in medicine and the physical world. Anyone can build on top of a model. Very few can navigate biology, regulation and real world complexity. The biggest AI companies may not be addictive

men turn 30 and rediscover physics and an obsession with the power grid

Finally it's here!

Quantum teleportation, explained by the person who helped invent it. Bill Wootters spoke to us at Perimeter Institute.

ironically the first thing ai killed was no-code everyone is now coding

out of necessity, the internet will soon be made up of geofenced, human-verified, invite-only micro-communities

This is so hilarious. Nothing can make Sam and Dario hold hands, not even the Prime Minister of India!

AlphaFold 3 just got a massive speed boost. 🚀 We’re introducing AlphaFast: a GPU-accelerated framework that cuts AF3 inference from >10 mins to ~25 seconds on a single GPU–a 22.8x speedup–without losing structural accuracy. More details below! 1/6 🧵

Delighted to share new Arc Institute work from our group on AI-accelerated lab-in-the-loop, in Science Magazine today One of the most remarkable things about biology is that it's digital. DNA, RNA, proteins: these are all sequences, and their function is directly encoded in

Polymaths will dominate the next 5 years, but only if they practice the skill of knowing what to ignore. You can learn and do anything now, meaning that it will become increasingly rare for a person to put time, attention, and care into one thing.

I am Open-Sourcing PyMolAI! Meet PyMolAI, an AI agent that can talk to your protein structures. Built on top of PyMOL, PyMolAI lets you interact with your structures in plain language. Whether you're: - Analyzing protein structures - Aligning complexes - Creating

Patrick Collison on what changes when biology becomes programmable: "We, humanity, have never cured a complex disease." "Most cardiovascular disease, most cancers, most autoimmune disease, most neurodegenerative disease... For none of them can we really say that we've cured it,

“The biggest beneficiaries of vibe coding are going to be… the shape rotators, not the wordcels” — Palmer Luckey

Ed Boyden - one of the elite scientists of our era - comes on the pod to talks brains, creating whole simulations of living things and where AI and humans will merge. Ed started at MIT at 16 and had two undergrad degrees and a masters degree four years later. He's been on an

Peter Thiel on culture: “If you define your culture like an HR person— it’s evidence you have no culture at all.” “Buzzwords tend to indicate the opposite of what they say— “I’m joking” or “frankly/honestly or “my friend.” “Culture is not having foosball tables or lava lamps.”