Today I used #RoseTTAFold to predict the 3D structure of a TAL effector. The crystallographic model (3V6T) is in orange. RoseTTAfold’s prediction is in blue. It took 30 minutes. THIS IS FREAKING AWESOME! 🤯 #proteinfolding

The most impressive scientific story of the year! Just wow. #DeepMind #AI #AlphaFold just solved 50-year-old grand challenge of #proteinfolding . What an exciting future ahead in #medicine #biology #drugdesign #bioengineering #gamechanger #science #compchem

It's official! #PPStasis2020 will take place in #Madrid the week of 28th September 2020. 📢 Pls RT!
More details will follow very soon!
#proteostasis #ubiquitin #autophagy #SUMO #proteolysis #vesicletraffic #ESCRT #ERAD #translation #UPR #proteinfolding #chaperones

IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12
#proteostasis #proteinfolding nature.com/articles/s4155…

All previous, current and vice chairs of #GRC #proteinfolding ! (Only 3 ppl missing) 20 years since first meeting! Stronger than ever😀

'ER redox homeostasis regulates proinsulin trafficking and insulin granule formation in the pancreatic islet β-cell' by Kristen E. Rohli, et al. --- new research article from Function

ow.ly/FatG50KXGT3

#EndoplasmicReticulum

The paper on decoding the entropic trap in the folding pathway rescued by the chaperonin is now out. #Proteinfolding CSIR-IGIB, Shiv Nadar University, Delhi NCR, Center For Computational Biology, IIIT-Delhi
sciencedirect.com/science/articl…

Nice study linking the redox status of the ER and proinsulin trafficking in pancreatic beta cells
#endoplasmicreticulum #redox #proteinfolding #proinsulin #proteintrafficking #insulin #betacells #diabetes #basicsciences

Ever wondered what happens to your protein when you add SDS🎇? Check out our new paper Chemical Science 🧪⚗️ ➡️cutt.ly/OdMopxM with fantastic Daniel Otzen & Michael 👇 #smFRET #proteinfolding iNANO - Interdisciplinary Nanoscience Center Center for Molecular Bioengineering at TU Dresden

We’re excited about the potential impact #AlphaFold may have on the future of biological research and scientific discovery. Thank you to the CASP organisers & the whole community - we look forward to the many years of hard work and discovery ahead: bit.ly/3qdko1Q

Intriguing aspect of the work Alexey Amunts is 20Å gap between exit / insertase, providing for additional factors and #proteinfolding milieu (which differs from bacteria that favor early compaction of TM helices). We visualize 32 AA of #MTATP6 here (red) in place of poly-Ala in 6zm5.

The renowned lab of Prof. Matthias Rief is taking their dynamic single-molecule research to the next level with their newly installed C-Trap®. Rief is a pioneer in studying #proteinfolding and function at the single-molecule level. TU München is now the home of two systems!⬇️

#Proteinfolding 🧬🧬 problem in Adiabatic 🐢🐢 #QuantumComputing setting leads to high circuit depths, not feasible for current devices. What is the way out? Digitized-counterdiabatic quantum computing (DCQC) 🐢+🚀 - 🐢. How? Read our latest #arXiv arxiv.org/abs/2212.13511

1/n 🧵

Our new #bioinfonotes about Programs for Visualizing Protein Structures has been published ! #biology #science #protein #pymol #rasmol #prosa #structure #visualization #structuralbiology #computationalbiology #biology notes #protein folding #bioinformatics

Unpacking complexity at the single-molecule level: happy to publish a smFRET study in Chemical Science on what SDS does to proteins (many different things!) pubs.rsc.org/en/content/art…. Great collaboration with Georg Krainer and Michael Michael Thanks to DK Frie Forsk.fond for support.

These findings highlight that protein folding is a journey, not just a destination, and there's much more to learn! Structure prediction is powerful, but still only one part of the #ProteinFolding story. 6/7

The IdentRA® test panel detects Rheumatoid Arthritis (RA) earlier than traditional blood tests by combining 14-3-3η protein with RF and anti-CCP. The 14-3-3η protein identifies 21% of early RA and 67% of established RA patients who test negative for RF and anti-CCP blood tests.

Data Science Noob : DeepMind's protein folding is a great breakthrough. AI rules.

Also DS Noob: How to train, test split.

It is ok not to know everything.

#DataScientist #DeepLearning #MachineLearning #AI #ProteinFolding

Just released online Trends in Biochemical Sciences - our lab's latest review on #cotranslationalfolding , written in collaboration with Chris Dobson sciencedirect.com/science/articl… #proteinfolding #ribosome #energylandscapes UCL Biosciences Cambridge Chemistry Wellcome #openaccess

✍️You can now register for #PragueProteinSpring 2023! This year, the conference focuses on #Proteins & #Diseases
🗓️4-7 May | Prague
pragueproteinspring.cz

Organized by IOCB Prague, ELIXIR Czech Republic and @Scientifika

#ProteinFolding #ProteinAggregation #IntrinsicallyDisorderedProteins

To my amazing partner, Daniela: you are my HSP70. When I’m all tangled up, you straighten me out… and then let me slowly become myself again. You are essential to my viability. 🥰😅 #AcademicChatter #proteinFolding

Explaining the fundamental dogma of molecular biology using interpretive aerial acrobatics Dr Nate Adams. #helicase #proteinFolding #kinetics #pint21

1M+ Verified Emails | 2.6M+ Podcast. Pull the entire database in one download, connect with show Hosts, get booked, and much more. Check out one of the World's largest Podcast Databases, do large data exports, and get granular in your search!

Latest from the lab! An improved version of REX for IDPs (His-5) and metamorphic proteins (RfaH). And of course alanine dipeptide, Trp Cage and Beta hairpin.

#beyondalaninedipeptide #metamorphicproteins #proteinfolding BPS IDP Subgroup IDPseminars The Biomolecular Condensate Fan Club IDP GRC PLUMED

High resolution ensemble description of metamorphic and intrinsically disordered proteins using an efficient hybrid parallel ... biorxiv.org/cgi/content/sh… #biorxiv_biophys

#ProteinFolding in the house Blue Valley - CAPS #hydrophobic #hydrophilic #saltbridge #disulfidebond On our path to ASBMB conference in April...