$PRME has achieved ~80% of hepatocytes (or ~50% whole liver editing) precise prime editing in vivo in humanized mice, with fidelity ratio >200.

Liver? Stomach? These cells from chapter 258 require a review of histology hehe
Without going deeper, they look like liver cells (hepatocytes) 😅

#jjk258 #JujutsuKaisen

#CryostaX #hepatocytes are now available on BioIVT .com! Created using a patented method, users can skip the water bath thawing step and easily pool donors without undergoing a second cryopreservation step. Learn more: hubs.ly/Q02w7Z5g0

#ADME #DMPK

[1:9]
Diabetes
Insulin Resistance
Naringenin potentiates intracellular signaling responses to low insulin doses by sensitizing hepatocytes to insulin.[1:10]
Naringin improves overall insulin sensitivity and glucose tolerance.

Hepatocytes and the art of killing #Plasmodium softly dlvr.it/T6WwSC Trends in Parasitology

BeCytes aims to be a fundamental partner for creating reliable preclinical models. We are experts in providing human and animal hepatic cells.

We can provide primary hepatocytes together with NPCs from the same donor.

➡️ bit.ly/predict-drug-i…

#DILI #liverfailure #spheroids

Researchers characterized stressor-specific changes in senescence phenotype, its related molecular patterns, and 🧫 cellular bioenergetics in primary 🐭 mouse #hepatocytes and hepatocyte-derived liver #organoids .

🔗 bit.ly/4agxG3F

Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase - Gabriella Darmasaputra Cindy Geerlings matilde galli et al Hubrecht Institute use fetal-derived hepatocyte organoids to investigate the regulation of endomitosis in vitro hubs.la/Q02wPPkc0

𝑪𝒐𝒏𝒈𝒓𝒂𝒕𝒖𝒍𝒂𝒕𝒊𝒐𝒏𝒔 to 𝐉𝐚𝐦𝐞𝐬 𝐃𝐚𝐯𝐞 𝐕. 𝐂𝐡𝐮𝐚 of Batch Hepatocytes for being awarded the 𝐓𝐨𝐩 𝟏 𝐍𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐀𝐰𝐚𝐫𝐝𝐞𝐞 of the “Mga Natatanging Mag-aaral ng Medisina sa Pilipinas 2024” and “Natatanging Mag-aaral ng Medisina sa Liderato” during the

Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes eurekamag.com/research/010/8…

New paper alert: liver steatosis in #SMA is driven by intrinsic defects in #mitochondria in #hepatocytes In collaboration with Crystal Yeo, MD PhD in Journal of Clinical Investigation tinyurl.com/mur4rm2x SMA-Europe Spinal Muscular Atrophy UK Cure SMA UoA Medicine, Medical Sciences and Nutrition

May Editor Pick: Downregulation of ANGPTL3 in human hepatocytes increases intracellular triglyceride content through a reduction in energy substrate utilization
ahajrnls.org/3VgVBfg

Intrigued by 3D hepatocyte culture? Can hepatocytes maintain zonation in vitro to study liver cell lineages? How can hepatocytes contribute to CCA after liver damage? Check out beautiful poster by fabulous PhD student Caitlin McCaffrey at AMMF, its a corker!

Kevin McKernan Some useful literature to remind us that ALC-0315 can penetrate lipid bylayer of any kind of cell, with preference for hepatocytes. The mRNA-LNP complex can be very unstable at a given T and pH.

1.sciencedirect.com/science/articl…
2.pubs.acs.org/doi/10.1021/ac…
3.pubs.acs.org/doi/10.1021/ac…

... and the hepatocytes screamed

On Thursday at 4:30pm EST, Dr. Marco De Giorgi will present new technology that dramatically increases the number of precisely repaired hepatocytes in the liver, using essential genes for selection. Targeted Gene Insertion Session, Ballroom 3.😎 #ASGCT2024 Somatic Cell Genome Editing (SCGE) Outreach

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3 dlvr.it/T6dzvq

3
'IGF-I does inhibit the expression of gluconeogenesis genes (55–57) by a mechanism similar to that of insulin albeit through different membrane receptors (57).'
Discussion: Hepatocytes don't have IGF-1 receptors. How can it inhibit gluconeogenesis then?

Binucleated human hepatocytes arise thru late cytokinetic regression during endomitosis M phase. In JCellBiol, Gabriella Darmasaputra Cindy Geerlings matilde galli et al use fetal-derived hepatocyte organoids to investigate the regulation of endomitosis in vitro hubs.ly/Q02wQx5d0

🎉Happy Friday! For your weekend reading🔓 'ATF4-mediated #CD36 upregulation contributes to #palmitate -induced #lipotoxicity in hepatocytes' by Alexandra Griffiths et al.

ow.ly/qOoe50RhzJ7

#SuggestedRead #ajpgi #GITwitter