Dr. Pashtoon Kasi (Pashtoon Kasi MD, MS), the WCM Englander Institute for Precision Medicine's Director of #ColonCancer Research and Director of Liquid Biopsy Research, spoke with OncLive.com on the potential of #ctDNA to guide further adjuvant treatment decisions in CRC and other tumor types.

onclive.com/view/dr-kasi-o…

Gratified to see our work on #ctDNA molecular response during #immunotherapy featured in ⁦Society for Immunotherapy of Cancer⁩ #AACR24 highlights! ⁦AACR⁩ ⁦⁦Johns Hopkins Thoracic Oncology⁩ ⁦Johns Hopkins Medicine⁩ ⁦Lavanya Sivapalan⁩ sitcancer.org/blogs/thomas-m…

Nuria Kotecki, MD presenting first results from the Brainstorm Program : CSF-ctDNA as a Surrogate for Tumor Tissue DNA in BC patients with CNS Metastases 🧠🧬 AACR Institut Jules Bordet Instituut Oncodistinct Network
#bcbm #ctDNA #AACR24

#AILCC24

Natasha Leighl University Health Network⁩ summarizes the major advances in liquid biopsy for nsclc, indicating new data/applications:

- FLAURA2, pre Tx ctDNA+ identifies those who may benefit
- MRD in early stage

@iaslc ⁦⁦#IrishLungCancerAlliance⁩ #LCSM

FLAURA2- Baseline detection of ctDNA may identify a subgroup of pts who derive most benefit from addition of chemoT to osimertinib as first line trtt for EGFRmut NSCLC by P.Jänne at #AACR24 EGFR Resisters Dana Farber's EGFR-Mutant Lung Cancer Center Gustave Roussy Dana-Farber News

This year's Pan-Tumor conference by CCRAN focuses on biomarker testing and comprehensive genomic profiling (CGP) to help you:

Get timely access to biomarker testing results
Understand the importance of CGP in treatment decisions
Learn about ctDNA testing for cancer management

#aacr24 beautiful introduction from Catherine Panabieres and Klaus Pantel to the minisimposiun on #liquidbiopsy : after #CTCs , that are the original analites which gave the name to liquid biopsy (As a comparison with tissue biopsy), to #ctDNA and #EVs up to the liquid miccobiopsy!

Exploratory #ctDNA analysis of the FLAURA2 trial by Pasi Jänne
Dana-Farber #AACR24
👉 Comparable EGFR mutation clearance in ctDNA at 6 weeks, in both arms.
EGFR Resisters #LCSM

Many congratulations to Wing Kin Liu for his AACR Scholar in Training Award presenting today at #AACR24 his work on tracking metastatic burden of disease using longitudinal imaging in relation to tumour genomics and ctDNA in the #TRACERx and #PEACE studies.

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
Science Magazine
doi.org/10.1126/scienc…
👉liver resident macrophages limit half-life of cfDNA
👉nanoparticles🚫clearance
😅Really cool & could help to boost sensitivity of ctDNA…

Equitable access to advanced biomarker testing is crucial for metastatic cancer patients in Canada. Join CCRAN's Pan-Tumor Biomarker Conference (June 20-21) to discuss timely biomarker results, comprehensive genomic profiling (CGP), ctDNA and more.

I'm 4 years #StageNED
NED until proven otherwise. My MRI is full of 'might be something, probably nothing, could be something...'🤪 but my CEA has increased by 66% for the first time in 4.5 years (barely abnormal), so my Onc is re-testing in 2 months alongside a CTDNA test👇

Nice article in Journal of Clinical Oncology about current evidence and ongoing trials for optimizing post neoadjuvant treatment in EBC pts who get PCR.
Note that ctDNA based MRD has not yet proven to be beneficial for treatment decisions for EBC. We need better biomakers. Great article by 👍…

#EAU24 #checkmate274 +ve DFS early +ve OS #IM010 -ve for both. #AMBASSADOR +ve DFS early -ve OS. Perhaps too early. How do we explain. Subsequent therapy hard to read. dynamic. Maybe ctDNA+ trials will have clearer signals from more likely events.

Comprehensive roundup of where ctDNA fits into lung cancer guidelines right now from Prof Natasha Leighl at the All-Ireland Lung Cancer Conference

Value is clear for upfront testing alongside tissue...

Next stops... Maybe MRD after surgery? Teatment monitoring during XRT?

New record! 🩸

They took FIVE vials of blood for my CtDNA + normal labs.

Joke’s on them, now I can get my BCC (blood caffeine content) higher faster.

Seriously, though, CtDNA is awesome - more/newer screening tech makes me feel safer.

#thankscancer #melanoma #mentalhealth

The potential value of ctDNA Tumour Fraction for Liquid Biopsy - great work from Christian Rolfo and colleagues AACR #AACR24

FLAURA2 exploratory analysis discussion by Marina Garassino at #AACR24 :
🔺dynamic ctDNA analysis not useful for clinical decisions
🔹baseline detection of EGFRm is prognostic and may select for a higher degree of clinical benefit from Osi+CT
AACR

Arndt Vogel Science Magazine Cool indeed! Optimizing these assays is a must to maximize their clinical utility. #ctDNA