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#PrecisionMedicine 👀👆🏾🧵 on a gene that I just learnt about 2m ago on #ctDNA &🏃. 🧬ERRFI1 🟢ERBB Receptor Feedback Inhibitor 1 ❓pronounced as ERR-FY-1️⃣ 2m of ERLOTINIB💊 Within weeks bilirubin📉 albumin📈 PS⬆️🙌🏾 #cholangiocarcinoma CtDNA VAF% 21%➡️3%👏🏾 Before➡️After💊2m

#LiquidBiopsies👇🏽this is 🆒! 💡Less about the assay but more about the approach/science. For patients getting liquid biopsies (#ctDNA), good idea by companies reporting other relevant biomarkers. ✔️Secondary germline🧬 ✔️Pharmacogenomics💊 ✔️HLA🩸 ✔️Viral e.g. HPV🦠 OncoAlert

🚨 STELLAR-303 makes history! First-ever Ph3 trial to show OS benefit of IO in MSS CRC 🎯 Years of grit & belief led us here 🥹 Endless thanks to Exelixis⁩ for the trust & Dr. Hecht for leading this global win with me! 🎉 ⁦UPMC Hillman Cancer Center⁩ ir.exelixis.com/news-releases/…

📺 Axiom Healthcare Strategies townhall. Now available at YouTube. 🙌🏽Love the cross disciplinary takes and discussions post ASCO. From immunotherapy/neoadjuvant paradigm shifts, to novel targets/molecules. In particular antibody-drug conjugates 🎯>〰️🔸. OncoAlert youtu.be/aTxqfIAePRQ?si…

Grateful to begin serving as Senior Editor for Clinical Cancer Research (Clinical Cancer Research), a journal I respect and love so much. Cool opportunity and very excited to work with Dr. Timothy Yap, Marlowe S Tessmer and the whole editorial crew! aacrjournals.org/clincancerres/…

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Everything is ready to start the #ESMOGI2025, #GastrointestinalCancers, #ESMOAmbassadors, ESMO - Eur. Oncology

Congrats to all! Also on the list: PhD candidate in my group Lauren van den Dungen presenting the PUMA study: pembrozumab and organ preservation in unresectable, non-metastatic dMMR CrC. #107P Friday poster session. #proudPI ESMO - Eur. Oncology #ESMOambassadors The Netherlands Cancer Institute

Medical Oncology team representation from Fundación Jiménez Díaz at ESMO - Eur. Oncology #ESMOGI25 Ready for four days of education, scientific exchange and networking 🤩🥳😊🫶 PD: thanks to everyone back at home taking care of our patients and allowing us to be here ❤️ (I don’t say this enough)

Small @myesmo #ESMOGI25 reunion in the faculty room! Great way to start the AM. Some of my fave people: Dr. Eileen O’Reilly, Angela Lamarca and Karyn Goodman, MD, MS ☹️Missed our photo 📸opportunity with Rachel Riechelmann! #ESMOAmbassadors #cancer #CancerResearch

Looking forward to the controversy session on organ preservation in dMMR/MSI colon cancers! 🥊 join us in Barcelona room! ESMO - Eur. Oncology #ESMOAmbassadors #ESMOGI25

Keynote lecture now by Frank Sinicrope, MD on CRC screening using blood-based tests and more. Chaired by Eric van Cutsem. ESMO - Eur. Oncology #ESMOAmbassadors #ESMOGI25

🟢IO for MSS CRC ESMO - Eur. Oncology #ESMOGI25 💉Trials of IO for unselected CRC 💉IO in patients with or without liver met 💉Neoadj BOT/BAL for pMMR CRC 💉Inducing mutability in pMMR CRC #cancer #oncology #colon #colorectal #MedX

Great overview by Michael overman of pMMR #CRC and efforts to modulate for immunotherapy response. Important to learn from negative studies, but also consider that responses might be different in earlier disease stages. #ESMOAmbassadors #ESMOGI25

23P – #ESMOGI25 GITuD real-world study, 44% of dMMR/MSI-H CRCs (MLH1–/MAPK WT) had actionable alterations (NTRK, RET) vs 0% in non-CRC. NTRK fusions were associated with worse 5-year OS (33% vs 100%, p=0.034), suggesting a role in primary resistance to ICI.

Happy #4thOfJuly from all of us at City of Hope Orange County as we celebrate independence and hope for all. 💙

Every cancer patient deserves a complete diagnosis.

Bye bye Barcelona, very busy but very fruitful ESMO - Eur. Oncology #ESMOGI25 Full of science, networking and colleagues that are becoming a second family #ESMOGI26 📍Munich 🗓️1-4 July 2026 #ESMOAmbassadors

“You are what you eat,” as they say. 🎙️Here’s the link to the interview and insights with Business Insider 🗞️ 📰. Hilary Brueck ✍️ What we put on our plate matters more than ever. 💡Complex interplay of diet and microbiome. 🔗 businessinsider.com/colon-cancer-d…