#Melatonin -induced upregulation of telomerase activity interferes with #macrophage #mitochondrial #metabolism and suppresses NLRP3 inflammasome activation in the treatment of #Pneumonia
sciencedirect.com/science/articl…

#Nicotine improves DSS-induced colitis by inhibiting NLRP3 and altering gut #microbiota
sciencedirect.com/org/science/ar…

最新：ニコチンは、NLRP3を阻害し、腸内細菌叢を変化させることで、DSS誘発性大腸炎を改善します

潰瘍性大腸炎は、直腸と結腸に影響を及ぼす慢性再発性炎症性疾患です。多数の疫学的研究により、喫煙が潰瘍性大腸炎の保護因子であることが確認されています。
🇯🇵www-sciencedirect-com.translate.goog/org/science/ar…

Recent research suggests that we might be able to turn down the volume on this alarm through something within our control: our diet and lifestyle choices, particularly through fasting and ketogenic interventions.

The NLRP3 inflammasome is like a guard that, (4/18)

Here, the researchers confirmed that SARS-CoV-2 viroporins ORF3a, E and M are capable of triggering NLRP3 inflammasome activation in human macrophages and inducing pyroptosis-like cell death in alveolar epithelial and endothelial cells. 4/

Explore #immunometabolism control by #NLRP3 #inflammasome activation with @‌PelegrinPablo @imib_Arrixaca, @‌olafgross_lab and @‌ClareBryant13 at #Inflammazoom on April 29.
Register now!
bit.ly/4dgEZLu

Scientists are getting closer to cracking the code on neurodegenerative diseases like Alzheimer's & Parkinson's. This new research highlights some key findings!

Read the article at: loom.ly/K_2A9zw

#chronicinflammation #inflammasome #NLRP3 #science #neurology #health

A clue? Inhibits host response from other human cases. #h5N1

Identification of a short sequence motif in the influenza A virus pathogenicity factor PB1-F2 required for inhibition of human NLRP3 | Journal of Virology journals.asm.org/doi/10.1128/jv…

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Inhibits the NLRP3 inflammasome and decreases levels of proteins related to the TRL4 signaling pathway, alleviating CIRI.

From periphery to center stage: 50 years of advancements in innate immunity

1973: DCs
1975: TNF
1989: PRR
1996: TLR4
2000: TLR9/3/5
2002: Inflammasome
2013: cGAS
2015: Gasdermin
2022: NLRP3

High glycolytic flux and NADH/CtBP/FOXP1 pathway to modulate endothelial NLRP3 inflammasome activation in atherogenesis.
Source: Endothelial NLRP3 inflammasome regulation in #atherosclerosis , European Society of Cardiology Cardiovascular Research, 2024, doi.org/10.1093/cvr/cv…

The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome biorxiv.org/content/10.110…

5) Inflammasomes are multiprotein complexes containing NLR sensors like NLRP3 that activate caspase-1 and IL-1b/IL-18 release in response to microbes and danger signals.

Coudereau's team explains how the activation of NLRP3 and immunosuppression concomitantly occur in the delayed stage of sepsis in this issue of #JLB buff.ly/4ajit2p

Cytosolic mtDNA–cGAS–STING axis contributes to sepsis-induced acute kidney injury via activating the NLRP3 inflamma… link.springer.com/10.1007/s10157…

4) Ageing and social isolation upregulate microglia reactivity in the hippocampus, 5) Social isolation increases NLRP3 inflammasome priming in the hippocampus and 7) Ageing, but not social isolation, increases the expression of proinflammatory cytokines in the hippocampus.

Join us 30th April 2pm for the WEHI (Walter and Eliza Hall Institute) #Parkinson 's seminar from Assoc Prof Richard Gordon from QUT UQ News on targeting NLRP3 in Parkinson's us02web.zoom.us/j/82263864360?…

NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction

academic.oup.com/cardiovascres/…

3) The viroporins were shown to activate the NLRP3 inflammasome in human macrophage cell lines, leading to pyroptosis-like cell death and IL-1β release. This activation was dependent on NLRP3 to some extent.

Activation of the Nrf2/ARE signaling pathway ameliorates hyperlipidemia-induced renal tubular epithelial cell injury by inhibiting mtROS-mediated NLRP3 inflammasome activation dlvr.it/T5wn6J #FrontImmunol