You have to do nothing to be who you are. Nothing at all.

H. W. L. Poonja

from Waking Up

An excellent thread about Evanegelos' Evangelos Giampazolias discovery below.

Very excited to share our latest work, out today in Science Magazine, on the serendipitous finding that vitamin D ☀️ regulates the gut microbiome to promote cancer immunity🦠 science.org/doi/10.1126/sc… 🧵👇 Caetano Reis e Sousa The Crick

We are proud to introduce our global atlas of substrate specificities for the human serine/threonine kinome, now on bioRxiv!

Work led by Jared Johnson and Tomer M. Yaron-Barir together with Ben Turk and Michael Yaffe

#TheKinaseLibrary #KL #part1

1/6

biorxiv.org/content/10.110…

Exploratory physiological experiments are not clinical trials - Cell⁩ ⁦Cell Metabolism⁩

Some considerations to take into account when performing health-related interventions, including exercise or diet.

Thx Erik A. Richter⁩ 👍 sciencedirect.com/science/articl…

science.org/doi/10.1126/sc…

very exciting findings from Evangelos Giampazolias
& Co!

science.org/doi/10.1126/sc…

congratulations to Sinika Henschke and the rest of the team for this groundbreaking discovery!

science.org/doi/10.1126/sc…

Replication and Transcription of Human Mitochondrial DNA | Annual Reviews - go.shr.lc/3VMsNvA

Online now in Cell Metabolism: we discuss regulation of skeletal muscle's adaptation to exercise from a tissue immunology perspective, highlight relevance to disease and aging, & propose avenues for future exploration. authors.elsevier.com/c/1i~Wj5WXUlWj…

Presenting metabolomics analyses: what is in a number? embopress.org/doi/full/10.10…

JMeiser_lab and I wrote this short piece to raise awareness about how present metabolomics data. We hope you will find it useful. Any comment is welcome! thanks Daniel Klimmeck for the support!

Ever wondered how to present your #metabolism #data best? A new #methods commentary series The EMBO Journal gives advice! To start JMeiser_lab and Christian Frezza FrezzaLab present guidance on how to reliably present and interpret #metabolomics results: embopress.org/doi/full/10.10…

Krebs cycle succinate-CoA ligase SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression
embopress.org/doi/full/10.10…

🚨Transcription and Chromatin UK is back for 2024🚨
We will be in Newcastle from 25th to 27 Sept. Register your interest so you're the first to know when registration opens 🧬
biochemistry.org/events-and-tra…

'PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function'
nature.com/articles/s4158…

'Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo'
nature.com/articles/s4158…

'Single-cell analysis reveals context-dependent, cell-level selection of mtDNA'

congrats to Vamsi Mootha
team!

nature.com/articles/s4158…

'PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells'
nature.com/articles/s4158…

'Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers'
nature.com/articles/s4158…

Data from longest running multicellularity evolution exp by Will Ratcliff 👏🏾👏🏾💥💥💥
'...we found that tetraploidy evolved because it confers immediate fitness benefits in this environment, by producing larger, longer cells that yield larger clusters.'

biorxiv.org/content/10.110…