Elevated Lipoprotein(a) and Risk of #AtrialFibrillation : An Observational and #MendelianRandomization Study
Pedrum Shemirani SrChong Sukrit Narula Matt Lanktree | #NephroGenetics Marie Pigeyre G Pare Genetics and Molecular Epidemiology Lab et al
JACC Journals
jacc.org/doi/10.1016/j.…
#genetics #biobank #Lpa #ASCVD #afib #EPeeps
Honoured to represent #Burundi at the genomic epidemiology conference for African scientists in kilifi coast, Kenya, the 1st #Mendelianrandomization conference in Africa #GEfAS MRC IEU KEMRI-Wellcome Trust IDeAL, Africa
Thanks Prof Helen Coleman for inviting Ryan Langdon Emma Hazelwood and Alice Carter to QUB Public Health to teach #mendelianrandomization . I hope there were many good research ideas sparked off by the course! MRC IEU ICEP Science and Innovation at Cancer Research UK
In this review by Claudia Lamina, #MendelianRandomization methods have been used to estimate the extent of #Lpa ⬇️ that would be required to yield a clinically meaningful ⬇️ in outcomes in clinical intervention trials
Marlys Koschinsky The Kronenberg Lab
atherosclerosis-journal.com/article/S0021-…
Our paper using multivariable #mendelianrandomization to assess the #causal effect of years ovulating, live #births , #BMI , age at #menarche and #menopause on #endometrialcancer are available online: bmcmedicine.biomedcentral.com/articles/10.11…
Huge effort from Shannon D'Urso!
UiO - Det medisinske fakultet Institute for Molecular Bioscience
'But correlation is not causation!' We then used #Mendelianrandomization (MR) analyses to ask, which of these associations are more likely to be causal?
Factors like confiding in others 💕 (risk-reducing), and TV time 📺 (risk-increasing), were still supported.
4/n
Excited to share that our paper about DNAm mediation through transcript levels is now published Nature Communications! nature.com/articles/s4146… Very grateful to all co-authors Chiara Auwerx Kaido Lepik Eleonora Porcu Zoltán Kutalik for their precious contribution!
#omics #GWAS #MendelianRandomization
Read about a LiDAR-based method that generates #HighDefinition #HD intersection maps for #AutonomoudDriving automatically and quickly in this #IEEECAA #JournalofAutomaticaSinica study:
ow.ly/n7c550OUxL2
Excited to be starting a PhD in Oct with george davey smith Tom Richardson Jess Tyrrell & Tim Frayling at the MRC IEU using genetics to understand the way modifiable factors in early life influence our risk of disease #Mendelianrandomization #geneticepidemiology #diseaseprevention
Excited. Been awarded with an EU Marie Sklodovska-Curie #IndividualFellowhip MarieSkłodowskaCurie Horizon 2020 #MicrobiomeGenomics #GutTissue #GeneExpression #ColorectalCancer #MendelianRandomization IDIBELL #VictorMoreno APC Microbiome Ireland #PaulOToole University of Bristol Nicholas Timpson Thank you !!!!
Happy to be in Bristol for a crash course in #MendelianRandomization . Been waiting for this!! Dr Luisa Zuccolo 💙💛 TARG Bristol CapiceProject #CAPICEBristol
It was amazing to work with so many great people from COVID-19 Host Genetics Initiative on this! Here I lead the #MendelianRandomization working group (w/ Laura,
Eirini Marouli, Camelia Minica Jeanne Savage, Joseph Buxbaum) to identify modifiable risk factors for infection and disease severity.
Excellent work from Salim S. Hayek, MD on #suPAR in heart failure. Together with the recent paper on suPAR using MendelianRandomization jci.org/articles/view/…, data suggest #suPAR to be a target for new treatments in #heart and #kidney disease.
U-M Frankel CVC Venk Murthy MD PhD Am Soc Nephrology
Just have finished #MendelianRandomization course University of Bristol an amazing experience on ultimately interesting field of research. Thank u Kaitlin Hazel Wade (she/her) @DeborahLawlor2 & all brilliant tutors & organizers!!
An #RNASequencing approach proposed in #JournalOfPharmaceuticalAnalysis reveals differences in the transcriptional patterns of various cell lines in #PanaxGinseng and #PanaxNotoginseng
Read more: sciencedirect.com/science/articl…
#Telomere lengthening may offer little gain in later-life #health and increase #cancer risk
Great work led by @chia_ling_kuo on #telomeres and #ageing in UK Biobank
George KUCHEL Prof David Melzer
UConn Research Exeter Med School
Aging Cell
#MendelianRandomization
doi.org/10.1111/acel.1…
What a fabulous end to an incredible week!
Closing ceremony from Sarah Atkinson and dhow ride along the Kilifi Creek 🥰
Cup. Is. Full.
#Mendelianrandomization KEMRI-Wellcome Trust MRC IEU
🧬☀️🇰🇪
Really enjoying teaching on the #Mendelianrandomization course here in Kenya. Today Venexia Walker’s talk on drug target MR has attracted some wildlife! #GEfAS KEMRI-Wellcome Trust IDeAL, Africa
Brilliant to have so many QUB Public Health researchers joining a fantastic bespoke 2 day MR course welcoming ICEP & Integrative Epi Unit University of Bristol researchers Dr Ryan Langdon, Dr Alice Carter & Emma Hazelwood. Thank you!
Influence of dyslipidaemia on left ventricle unravelled by #MendelianRandomization Downstream utility of genetic instruments from #GWAS Steffen Petersen, Patricia Munroe Mihir Sanghvi William Harvey Research Institute UK Biobank @CardiacJoshi
The Effect of Blood Lipids on the Left Ventricle jacc.org/doi/10.1016/j.…
I am finding the book 'Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation' from Stephen Burgess and Simon G. Thompson a wonderful reading for people who, like me, are trying to learn more about the topic! #mendelianrandomization #epidemiology
⬆️ central adiposity ➡️ ⬆️ serum calcium
⬆️serum calcium concentration ➡️⬆️ risk of #KidneyStones
Observational analyses show associations, #MendelianRandomization analyses measure causal effects.
Next question: how?
Nuffield Department of Surgical Sciences OCDEM Oxford Population Health (OxPop) NDORMS Jelena
#Parkinsons #mendelianrandomization Research Portal is out... really hope people like it.
Sara Bandres Ciga Karl Heilbron 23andMe Research & Therapeutics PDgenetics.org Andrew Mike A. Nalls Preventive Neurology Unit Cure Parkinson's Parkinson's UK Barts Charity
onlinelibrary.wiley.com/doi/full/10.10…
Very happy to share our preprint; central adiposity causes kidney stones via altered calcium homeostasis. Other components of metabolic syndrome unlikely to cause stones CEL Dominic Furniss Michael V Holmes (he/him) Ben Turney medrxiv.org/content/10.110…